Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides

The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on...

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Autores principales: Palikov, V. A., Terekhov, S. S., Palikova, Yu. A., Khokhlova, O. N., Kazakov, V. A., Dyachenko, I. A., Panteleev, S. V., Mokrushina, Yu. A., Knorre, V. D., Shamborant, O. G., Smirnov, I. V., Gabibov, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027/
https://www.ncbi.nlm.nih.gov/pubmed/30713772
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author Palikov, V. A.
Terekhov, S. S.
Palikova, Yu. A.
Khokhlova, O. N.
Kazakov, V. A.
Dyachenko, I. A.
Panteleev, S. V.
Mokrushina, Yu. A.
Knorre, V. D.
Shamborant, O. G.
Smirnov, I. V.
Gabibov, A. G.
author_facet Palikov, V. A.
Terekhov, S. S.
Palikova, Yu. A.
Khokhlova, O. N.
Kazakov, V. A.
Dyachenko, I. A.
Panteleev, S. V.
Mokrushina, Yu. A.
Knorre, V. D.
Shamborant, O. G.
Smirnov, I. V.
Gabibov, A. G.
author_sort Palikov, V. A.
collection PubMed
description The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning.
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spelling pubmed-63510272019-02-01 Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides Palikov, V. A. Terekhov, S. S. Palikova, Yu. A. Khokhlova, O. N. Kazakov, V. A. Dyachenko, I. A. Panteleev, S. V. Mokrushina, Yu. A. Knorre, V. D. Shamborant, O. G. Smirnov, I. V. Gabibov, A. G. Acta Naturae Research Article The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning. A.I. Gordeyev 2018 /pmc/articles/PMC6351027/ /pubmed/30713772 Text en Copyright ® 2018 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Palikov, V. A.
Terekhov, S. S.
Palikova, Yu. A.
Khokhlova, O. N.
Kazakov, V. A.
Dyachenko, I. A.
Panteleev, S. V.
Mokrushina, Yu. A.
Knorre, V. D.
Shamborant, O. G.
Smirnov, I. V.
Gabibov, A. G.
Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title_full Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title_fullStr Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title_full_unstemmed Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title_short Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides
title_sort mouse model for assessing the subchronic toxicity of organophosphate pesticides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027/
https://www.ncbi.nlm.nih.gov/pubmed/30713772
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