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The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B
Following systematic scrutiny of the evidence in support of the hypothesis that the cardioprotective mechanism of action of dexrazoxane is mediated by a ‘depletion’ or ‘downregulation’ of Top2β protein levels in heart tissue, the author concludes that this hypothesis is untenable. In seeking to unde...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cancer Intelligence
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351063/ https://www.ncbi.nlm.nih.gov/pubmed/30792806 http://dx.doi.org/10.3332/ecancer.2018.889 |