Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

PUF (PUmilio/FBF) RNA-binding proteins recognize distinct elements. In C. elegans, PUF-8 binds to an 8-nt motif and restricts proliferation in the germline. Conversely, FBF-2 recognizes a 9-nt element and promotes mitosis. To understand how motif divergence relates to biological function, we first d...

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Detalles Bibliográficos
Autores principales: Bhat, Vandita D, McCann, Kathleen L, Wang, Yeming, Fonseca, Dallas R, Shukla, Tarjani, Alexander, Jacqueline C, Qiu, Chen, Wickens, Marv, Lo, Te-Wen, Tanaka Hall, Traci M, Campbell, Zachary T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351103/
https://www.ncbi.nlm.nih.gov/pubmed/30652968
http://dx.doi.org/10.7554/eLife.43788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351103/
https://www.ncbi.nlm.nih.gov/pubmed/30652968
http://dx.doi.org/10.7554/eLife.43788

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