Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes

SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4...

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Detalles Bibliográficos
Autores principales: Cheung, Alan C. M., Díaz-Santín, Luis Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351133/
https://www.ncbi.nlm.nih.gov/pubmed/30375921
http://dx.doi.org/10.1080/21541264.2018.1530936
Descripción
Sumario:SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.

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