Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes

SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4...

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Detalles Bibliográficos
Autores principales: Cheung, Alan C. M., Díaz-Santín, Luis Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351133/
https://www.ncbi.nlm.nih.gov/pubmed/30375921
http://dx.doi.org/10.1080/21541264.2018.1530936
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author Cheung, Alan C. M.
Díaz-Santín, Luis Miguel
author_facet Cheung, Alan C. M.
Díaz-Santín, Luis Miguel
author_sort Cheung, Alan C. M.
collection PubMed
description SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.
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spelling pubmed-63511332019-02-06 Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes Cheung, Alan C. M. Díaz-Santín, Luis Miguel Transcription Point-of-View SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function. Taylor & Francis 2018-10-30 /pmc/articles/PMC6351133/ /pubmed/30375921 http://dx.doi.org/10.1080/21541264.2018.1530936 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Point-of-View
Cheung, Alan C. M.
Díaz-Santín, Luis Miguel
Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title_full Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title_fullStr Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title_full_unstemmed Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title_short Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes
title_sort share and share alike: the role of tra1 from the saga and nua4 coactivator complexes
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351133/
https://www.ncbi.nlm.nih.gov/pubmed/30375921
http://dx.doi.org/10.1080/21541264.2018.1530936
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