LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats

White matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a scavenger recept...

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Detalles Bibliográficos
Autores principales: Peng, Jianhua, Pang, Jinwei, Huang, Lei, Enkhjargal, Budbazar, Zhang, Tongyu, Mo, Jun, Wu, Pei, Xu, Weilin, Zuo, Yuchun, Peng, Jun, Zuo, Gang, Chen, Ligang, Tang, Jiping, Zhang, John H., Jiang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351270/
https://www.ncbi.nlm.nih.gov/pubmed/30703614
http://dx.doi.org/10.1016/j.redox.2019.101121

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