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Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy
The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called “immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chonnam National University Medical School
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351328/ https://www.ncbi.nlm.nih.gov/pubmed/30740334 http://dx.doi.org/10.4068/cmj.2019.55.1.1 |
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author | Ebara, Mitsuhiro |
author_facet | Ebara, Mitsuhiro |
author_sort | Ebara, Mitsuhiro |
collection | PubMed |
description | The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called “immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-inert biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their performance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane-inspired polymer and its post-inflammatory effects on immune cells in this article. |
format | Online Article Text |
id | pubmed-6351328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-63513282019-02-08 Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy Ebara, Mitsuhiro Chonnam Med J Review Article The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called “immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-inert biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their performance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane-inspired polymer and its post-inflammatory effects on immune cells in this article. Chonnam National University Medical School 2019-01 2019-01-25 /pmc/articles/PMC6351328/ /pubmed/30740334 http://dx.doi.org/10.4068/cmj.2019.55.1.1 Text en © Chonnam Medical Journal, 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ebara, Mitsuhiro Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title | Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title_full | Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title_fullStr | Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title_full_unstemmed | Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title_short | Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy |
title_sort | apoptotic cell-mimetic polymers for anti-inflammatory therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351328/ https://www.ncbi.nlm.nih.gov/pubmed/30740334 http://dx.doi.org/10.4068/cmj.2019.55.1.1 |
work_keys_str_mv | AT ebaramitsuhiro apoptoticcellmimeticpolymersforantiinflammatorytherapy |