Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells

Epidermal growth factor receptor (EGFR) inhibitors have limited efficacy in head and neck squamous cell carcinoma (HNSCC) due to various resistance mechanisms, such as activation of the insulin-like growth factor-1 receptor (IGF1R), which initiates pro-survival signaling. Survivin, a member of the i...

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Detalles Bibliográficos
Autores principales: Lehman, Christine E., Mendez, Rolando E., Dougherty, Michael I., Allak, Amir, Adejumo, Oluwayemisi L., Taniguchi, Linnea E., Khalil, Ashraf, Gioeli, Daniel G., Jameson, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351440/
https://www.ncbi.nlm.nih.gov/pubmed/30729097
http://dx.doi.org/10.3389/fonc.2019.00013

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