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Long Non-coding RNA in Neuronal Development and Neurological Disorders

Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several d...

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Detalles Bibliográficos
Autores principales: Li, Ling, Zhuang, Yingliang, Zhao, Xingsen, Li, Xuekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351443/
https://www.ncbi.nlm.nih.gov/pubmed/30728830
http://dx.doi.org/10.3389/fgene.2018.00744
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author Li, Ling
Zhuang, Yingliang
Zhao, Xingsen
Li, Xuekun
author_facet Li, Ling
Zhuang, Yingliang
Zhao, Xingsen
Li, Xuekun
author_sort Li, Ling
collection PubMed
description Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progress has been made in understanding the regulatory functions of lncRNAs in diverse biological processes, including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development etc. Dysregulation of lncRNAs is involved in multiple human diseases, especially neurological disorders. In this review, we summarize the recent progress made with regards to the function of lncRNAs and associated molecular mechanisms, focusing on neuronal development and neurological disorders.
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spelling pubmed-63514432019-02-06 Long Non-coding RNA in Neuronal Development and Neurological Disorders Li, Ling Zhuang, Yingliang Zhao, Xingsen Li, Xuekun Front Genet Genetics Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200 nt in length, and which do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progress has been made in understanding the regulatory functions of lncRNAs in diverse biological processes, including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development etc. Dysregulation of lncRNAs is involved in multiple human diseases, especially neurological disorders. In this review, we summarize the recent progress made with regards to the function of lncRNAs and associated molecular mechanisms, focusing on neuronal development and neurological disorders. Frontiers Media S.A. 2019-01-23 /pmc/articles/PMC6351443/ /pubmed/30728830 http://dx.doi.org/10.3389/fgene.2018.00744 Text en Copyright © 2019 Li, Zhuang, Zhao and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Ling
Zhuang, Yingliang
Zhao, Xingsen
Li, Xuekun
Long Non-coding RNA in Neuronal Development and Neurological Disorders
title Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_full Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_fullStr Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_full_unstemmed Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_short Long Non-coding RNA in Neuronal Development and Neurological Disorders
title_sort long non-coding rna in neuronal development and neurological disorders
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351443/
https://www.ncbi.nlm.nih.gov/pubmed/30728830
http://dx.doi.org/10.3389/fgene.2018.00744
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