Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions

Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar...

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Detalles Bibliográficos
Autores principales: Schindler, Daniel, Dai, Junbiao, Cai, Yizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351456/
https://www.ncbi.nlm.nih.gov/pubmed/29751161
http://dx.doi.org/10.1016/j.cbpa.2018.04.002
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author Schindler, Daniel
Dai, Junbiao
Cai, Yizhi
author_facet Schindler, Daniel
Dai, Junbiao
Cai, Yizhi
author_sort Schindler, Daniel
collection PubMed
description Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10 000 bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.
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spelling pubmed-63514562019-02-04 Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions Schindler, Daniel Dai, Junbiao Cai, Yizhi Curr Opin Chem Biol Article Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10 000 bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions. The Authors. Published by Elsevier Ltd. 2018-10 2018-05-09 /pmc/articles/PMC6351456/ /pubmed/29751161 http://dx.doi.org/10.1016/j.cbpa.2018.04.002 Text en © 2018 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schindler, Daniel
Dai, Junbiao
Cai, Yizhi
Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title_full Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title_fullStr Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title_full_unstemmed Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title_short Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
title_sort synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351456/
https://www.ncbi.nlm.nih.gov/pubmed/29751161
http://dx.doi.org/10.1016/j.cbpa.2018.04.002
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