Cargando…

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients. Personalization of target therapies remains, therefore, a challenge i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zolotovskaia, Marianna A., Sorokin, Maxim I., Emelianova, Anna A., Borisov, Nikolay M., Kuzmin, Denis V., Borger, Pieter, Garazha, Andrew V., Buzdin, Anton A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351482/ https://www.ncbi.nlm.nih.gov/pubmed/30728774 http://dx.doi.org/10.3389/fphar.2019.00001

Ejemplares similares

Algorithmic Annotation of Functional Roles for Components of 3,044 Human Molecular Pathways
por: Sorokin, Maxim, et al.
Publicado: (2021)

Anticancer Activity of the Goat Antimicrobial Peptide ChMAP-28
por: Emelianova, Anna A., et al.
Publicado: (2018)

Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers
por: Zolotovskaia, Marianna A., et al.
Publicado: (2019)

Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer
por: Zolotovskaia, Marianna A., et al.
Publicado: (2020)

OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization
por: Zolotovskaia, Marianna A., et al.
Publicado: (2022)

Cancer gene expression profiles associated with clinical outcomes to chemotherapy treatments
por: Borisov, Nicolas, et al.
Publicado: (2020)

Flexible Data Trimming Improves Performance of Global Machine Learning Methods in Omics-Based Personalized Oncology
por: Tkachev, Victor, et al.
Publicado: (2020)

Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways
por: Zolotovskaia, Marianna A., et al.
Publicado: (2022)

RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples
por: Sorokin, Maxim, et al.
Publicado: (2021)

Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs
por: Zhavoronkov, Alex, et al.
Publicado: (2014)

Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III
por: Marggraf, Mariana B., et al.
Publicado: (2018)

Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth
por: Kamashev, Dmitry, et al.
Publicado: (2021)

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology
por: Zolotovskaia, Marianna A., et al.
Publicado: (2020)

Algorithmically Reconstructed Molecular Pathways as the New Generation of Prognostic Molecular Biomarkers in Human Solid Cancers
por: Zolotovskaia, Marianna, et al.
Publicado: (2023)

Algorithmically Deduced FREM2 Molecular Pathway Is a Potent Grade and Survival Biomarker of Human Gliomas
por: Zolotovskaia, Marianna, et al.
Publicado: (2021)

Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution
por: Nikitin, Daniil, et al.
Publicado: (2019)

Correction: Nikitin, D., et al. Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution. Cells 2019, 8, 130
por: Nikitin, Daniil, et al.
Publicado: (2019)

FLOating-Window Projective Separator (FloWPS): A Data Trimming Tool for Support Vector Machines (SVM) to Improve Robustness of the Classifier
por: Tkachev, Victor, et al.
Publicado: (2019)

Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data
por: Sorokin, Maxim, et al.
Publicado: (2022)

High-Throughput Mutation Data Now Complement Transcriptomic Profiling: Advances in Molecular Pathway Activation Analysis Approach in Cancer Biology
por: Buzdin, Anton, et al.
Publicado: (2019)

Shambhala: a platform-agnostic data harmonizer for gene expression data
por: Borisov, Nicolas, et al.
Publicado: (2019)

Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins
por: Nikitin, Daniil, et al.
Publicado: (2018)

The Role of the Metabolism of Zinc and Manganese Ions in Human Cancerogenesis
por: Rozenberg, Julian Markovich, et al.
Publicado: (2022)

Uniformly shaped harmonization combines human transcriptomic data from different platforms while retaining their biological properties and differential gene expression patterns
por: Borisov, Nicolas, et al.
Publicado: (2023)

Experimentally Deduced Criteria for Detection of Clinically Relevant Fusion 3′ Oncogenes from FFPE Bulk RNA Sequencing Data
por: Rabushko, Elizaveta, et al.
Publicado: (2022)

RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report
por: Seryakov, Alexander, et al.
Publicado: (2021)

Better Agreement of Human Transcriptomic and Proteomic Cancer Expression Data at the Molecular Pathway Activation Level
por: Raevskiy, Mikhail, et al.
Publicado: (2022)

Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA
por: Buzdin, Anton A., et al.
Publicado: (2017)

A Review of Recent Studies on the Effects of SARS-CoV-2 Infection and SARS-CoV-2 Vaccines on Male Reproductive Health
por: Adamyan, Leila, et al.
Publicado: (2022)

MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways
por: Artcibasova, Alina V., et al.
Publicado: (2016)

Oncobox Bioinformatical Platform for Selecting Potentially Effective Combinations of Target Cancer Drugs Using High-Throughput Gene Expression Data
por: Sorokin, Maxim, et al.
Publicado: (2018)

DNA repair pathway activation features in follicular and papillary thyroid tumors, interrogated using 95 experimental RNA sequencing profiles
por: Vladimirova, Uliana, et al.
Publicado: (2021)

Combination of Antiretroviral Drugs Zidovudine and Efavirenz Impairs Tumor Growths in a Mouse Model of Cancer
por: Schneider, Marcel A., et al.
Publicado: (2021)

Case of multifocal glioblastoma with four fusion transcripts of ALK, FGFR2, NTRK2, and NTRK3 genes stresses the need for tumor tissue multisampling for transcriptomic analysis
por: Samii, Amir, et al.
Publicado: (2021)

Machine Learning Applicability for Classification of PAD/VCD Chemotherapy Response Using 53 Multiple Myeloma RNA Sequencing Profiles
por: Borisov, Nicolas, et al.
Publicado: (2021)

Large-Scale Profiling of Signaling Pathways Reveals a Distinct Demarcation between Normal and Extended Liver Resection
por: Borger, Pieter, et al.
Publicado: (2020)

Distinct Traits of Structural and Regulatory Evolutional Conservation of Human Genes with Specific Focus on Major Cancer Molecular Pathways
por: Zakharova, Galina, et al.
Publicado: (2023)

RNA Sequencing in Comparison to Immunohistochemistry for Measuring Cancer Biomarkers in Breast Cancer and Lung Cancer Specimens
por: Sorokin, Maxim, et al.
Publicado: (2020)

Characteristic patterns of microRNA expression in human bladder cancer
por: Zabolotneva, Anastasia A., et al.
Publicado: (2013)

COVID-19–associated inhibition of energy accumulation pathways in human semen samples
por: Adamyan, Leila, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h11lbh8t6lrp1bmagk0dcibq3v