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Regulation of human brown adipose tissue by adenosine and A(2A) receptors – studies with [(15)O]H(2)O and [(11)C]TMSX PET/CT

PURPOSE: Brown adipose tissue (BAT) has emerged as a potential target to combat obesity and diabetes, but novel strategies to activate BAT are needed. Adenosine and A(2A) receptor (A2AR) agonism activate BAT in rodents, and endogenous adenosine is released locally in BAT as a by-product of noradrena...

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Detalles Bibliográficos
Autores principales: Lahesmaa, Minna, Oikonen, Vesa, Helin, Semi, Luoto, Pauliina, U Din, Mueez, Pfeifer, Alexander, Nuutila, Pirjo, Virtanen, Kirsi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351510/
https://www.ncbi.nlm.nih.gov/pubmed/30105585
http://dx.doi.org/10.1007/s00259-018-4120-2