Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse

Tuberous Sclerosis Complex (TSC) is caused by mutations in TSC1 or TSC2, which encode negative regulators of the mTOR signaling pathway. The renal abnormalities associated with TSC include angiomyolipoma, cysts, and renal cell carcinoma. Here we report that specific ablation of Tsc1 using the mesenc...

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Detalles Bibliográficos
Autores principales: Wu, Zhixiang, Wu, Hongguang, Md, Shafiquzzaman, Yu, Guo, Habib, Samy L., Li, Baojie, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351533/
https://www.ncbi.nlm.nih.gov/pubmed/30696882
http://dx.doi.org/10.1038/s41598-018-37139-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351533/
https://www.ncbi.nlm.nih.gov/pubmed/30696882
http://dx.doi.org/10.1038/s41598-018-37139-9

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