Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling

Vascular calcification is associated with significant morbidity and mortality within diabetes, involving activation of osteogenic regulators and transcription factors. Recent evidence demonstrates the beneficial role of Sirtuin 1 (SIRT1), an NAD(+) dependant deacetylase, in improved insulin sensitiv...

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Detalles Bibliográficos
Autores principales: Bartoli-Leonard, F., Wilkinson, F. L., Schiro, A., Inglott, F. Serracino, Alexander, M. Y., Weston, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351547/
https://www.ncbi.nlm.nih.gov/pubmed/30696833
http://dx.doi.org/10.1038/s41598-018-37027-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351547/
https://www.ncbi.nlm.nih.gov/pubmed/30696833
http://dx.doi.org/10.1038/s41598-018-37027-2

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