Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-β-D-glucuronide (pNPG), the GUS orthologs that are most...

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Detalles Bibliográficos
Autores principales: Biernat, Kristen A., Pellock, Samuel J., Bhatt, Aadra P., Bivins, Marissa M., Walton, William G., Tran, Bich Ngoc T., Wei, Lianjie, Snider, Michael C., Cesmat, Andrew P., Tripathy, Ashutosh, Erie, Dorothy A., Redinbo, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351562/
https://www.ncbi.nlm.nih.gov/pubmed/30696850
http://dx.doi.org/10.1038/s41598-018-36069-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351562/
https://www.ncbi.nlm.nih.gov/pubmed/30696850
http://dx.doi.org/10.1038/s41598-018-36069-w

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