SLIME: robust, high-speed 3D microvascular mapping

Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in ex...

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Autores principales: Liu, Yehe, Broberg, Meredith C. G., Watanabe, Michiko, Rollins, Andrew M., Jenkins, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351571/
https://www.ncbi.nlm.nih.gov/pubmed/30696870
http://dx.doi.org/10.1038/s41598-018-37313-z
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author Liu, Yehe
Broberg, Meredith C. G.
Watanabe, Michiko
Rollins, Andrew M.
Jenkins, Michael W.
author_facet Liu, Yehe
Broberg, Meredith C. G.
Watanabe, Michiko
Rollins, Andrew M.
Jenkins, Michael W.
author_sort Liu, Yehe
collection PubMed
description Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.
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spelling pubmed-63515712019-01-30 SLIME: robust, high-speed 3D microvascular mapping Liu, Yehe Broberg, Meredith C. G. Watanabe, Michiko Rollins, Andrew M. Jenkins, Michael W. Sci Rep Article Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts. Nature Publishing Group UK 2019-01-29 /pmc/articles/PMC6351571/ /pubmed/30696870 http://dx.doi.org/10.1038/s41598-018-37313-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Yehe
Broberg, Meredith C. G.
Watanabe, Michiko
Rollins, Andrew M.
Jenkins, Michael W.
SLIME: robust, high-speed 3D microvascular mapping
title SLIME: robust, high-speed 3D microvascular mapping
title_full SLIME: robust, high-speed 3D microvascular mapping
title_fullStr SLIME: robust, high-speed 3D microvascular mapping
title_full_unstemmed SLIME: robust, high-speed 3D microvascular mapping
title_short SLIME: robust, high-speed 3D microvascular mapping
title_sort slime: robust, high-speed 3d microvascular mapping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351571/
https://www.ncbi.nlm.nih.gov/pubmed/30696870
http://dx.doi.org/10.1038/s41598-018-37313-z
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AT rollinsandrewm slimerobusthighspeed3dmicrovascularmapping
AT jenkinsmichaelw slimerobusthighspeed3dmicrovascularmapping

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