Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons

Spinal muscular atrophy is a motor neuron disorder caused by mutations in SMN1. The reasons for the selective vulnerability of motor neurons linked to SMN (encoded by SMN1) reduction remain unclear. Therefore, we performed deep RNA sequencing on human spinal muscular atrophy motor neurons to detect...

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Detalles Bibliográficos
Autores principales: Rizzo, Federica, Nizzardo, Monica, Vashisht, Shikha, Molteni, Erika, Melzi, Valentina, Taiana, Michela, Salani, Sabrina, Santonicola, Pamela, Di Schiavi, Elia, Bucchia, Monica, Bordoni, Andreina, Faravelli, Irene, Bresolin, Nereo, Comi, Giacomo Pietro, Pozzoli, Uberto, Corti, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351774/
https://www.ncbi.nlm.nih.gov/pubmed/30649277
http://dx.doi.org/10.1093/brain/awy330

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