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Nonalcoholic fatty liver disease in obese and nonobese pediatric patients

PURPOSE: Obesity is risk factor for nonalcoholic fatty liver disease (NAFLD). However, nonobese patients are also increasingly susceptible to NAFLD. The aim of this study was to compare the clinical characteristics of obese and nonobese pediatric patients with NAFLD. METHODS: We retrospectively stud...

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Autores principales: Kim, Eun Jeong, Kim, Hyun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351803/
https://www.ncbi.nlm.nih.gov/pubmed/30304905
http://dx.doi.org/10.3345/kjp.2018.06786
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author Kim, Eun Jeong
Kim, Hyun Jin
author_facet Kim, Eun Jeong
Kim, Hyun Jin
author_sort Kim, Eun Jeong
collection PubMed
description PURPOSE: Obesity is risk factor for nonalcoholic fatty liver disease (NAFLD). However, nonobese patients are also increasingly susceptible to NAFLD. The aim of this study was to compare the clinical characteristics of obese and nonobese pediatric patients with NAFLD. METHODS: We retrospectively studied 68 patients who were diagnosed with NAFLD between January 2010 and October 2016 at 10–18 years of age. Body mass index ≥95th percentile for age and sex was defined as obesity. Abdominal ultrasonography and laboratory, anthropometrics measurements were evaluated. RESULTS: Among the 68, 26 (38.2%) were nonobese patients. The ratio of male to female was 5.8:1, and the median age at diagnosis was 13 years (range, 10–17 years). Significant higher triglyceride (223.0 mg/dL vs. 145.9 mg/dL, P=0.047) and total cholesterol levels (211.6 mg/dL vs. 173.2 mg/dL, P=0.011) were shown in nonobese than obese patients. High-density lipoprotein cholesterol level <40 mg/dL (hazard ratio [HR], 6.5; 95% confidence interval [CI], 2.13–7.10; P=0.048), total cholesterol level >200mg/dL (HR, 5.6; 95% CI, 1.23–15.31; P=0.038) and abdominal obesity (HR, 2.53; 95% CI, 1.22–4.68; P=0.013) were significant risk factors for NAFLD in nonobese patients. CONCLUSION: Nonobese patients present a substantial proportion of pediatric NAFLD cases. Significant abnormal lipid concentrations were found in nonobese and abdominal obesity was important risk factor for nonobese NAFLD.
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spelling pubmed-63518032019-02-08 Nonalcoholic fatty liver disease in obese and nonobese pediatric patients Kim, Eun Jeong Kim, Hyun Jin Korean J Pediatr Original Article PURPOSE: Obesity is risk factor for nonalcoholic fatty liver disease (NAFLD). However, nonobese patients are also increasingly susceptible to NAFLD. The aim of this study was to compare the clinical characteristics of obese and nonobese pediatric patients with NAFLD. METHODS: We retrospectively studied 68 patients who were diagnosed with NAFLD between January 2010 and October 2016 at 10–18 years of age. Body mass index ≥95th percentile for age and sex was defined as obesity. Abdominal ultrasonography and laboratory, anthropometrics measurements were evaluated. RESULTS: Among the 68, 26 (38.2%) were nonobese patients. The ratio of male to female was 5.8:1, and the median age at diagnosis was 13 years (range, 10–17 years). Significant higher triglyceride (223.0 mg/dL vs. 145.9 mg/dL, P=0.047) and total cholesterol levels (211.6 mg/dL vs. 173.2 mg/dL, P=0.011) were shown in nonobese than obese patients. High-density lipoprotein cholesterol level <40 mg/dL (hazard ratio [HR], 6.5; 95% confidence interval [CI], 2.13–7.10; P=0.048), total cholesterol level >200mg/dL (HR, 5.6; 95% CI, 1.23–15.31; P=0.038) and abdominal obesity (HR, 2.53; 95% CI, 1.22–4.68; P=0.013) were significant risk factors for NAFLD in nonobese patients. CONCLUSION: Nonobese patients present a substantial proportion of pediatric NAFLD cases. Significant abnormal lipid concentrations were found in nonobese and abdominal obesity was important risk factor for nonobese NAFLD. Korean Pediatric Society 2019-01 2018-09-17 /pmc/articles/PMC6351803/ /pubmed/30304905 http://dx.doi.org/10.3345/kjp.2018.06786 Text en Copyright © 2019 by The Korean Pediatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Eun Jeong
Kim, Hyun Jin
Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title_full Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title_fullStr Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title_full_unstemmed Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title_short Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
title_sort nonalcoholic fatty liver disease in obese and nonobese pediatric patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351803/
https://www.ncbi.nlm.nih.gov/pubmed/30304905
http://dx.doi.org/10.3345/kjp.2018.06786
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