Female XX sex chromosomes increase survival and extend lifespan in aging mice

Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and femal...

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Detalles Bibliográficos
Autores principales: Davis, Emily J., Lobach, Iryna, Dubal, Dena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351820/
https://www.ncbi.nlm.nih.gov/pubmed/30560587
http://dx.doi.org/10.1111/acel.12871
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author Davis, Emily J.
Lobach, Iryna
Dubal, Dena B.
author_facet Davis, Emily J.
Lobach, Iryna
Dubal, Dena B.
author_sort Davis, Emily J.
collection PubMed
description Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex‐based differences in aging could lead to new pathways to counter age‐induced decline in both sexes.
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spelling pubmed-63518202019-02-07 Female XX sex chromosomes increase survival and extend lifespan in aging mice Davis, Emily J. Lobach, Iryna Dubal, Dena B. Aging Cell Short Take Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex‐based differences in aging could lead to new pathways to counter age‐induced decline in both sexes. John Wiley and Sons Inc. 2018-12-17 2019-02 /pmc/articles/PMC6351820/ /pubmed/30560587 http://dx.doi.org/10.1111/acel.12871 Text en © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Take
Davis, Emily J.
Lobach, Iryna
Dubal, Dena B.
Female XX sex chromosomes increase survival and extend lifespan in aging mice
title Female XX sex chromosomes increase survival and extend lifespan in aging mice
title_full Female XX sex chromosomes increase survival and extend lifespan in aging mice
title_fullStr Female XX sex chromosomes increase survival and extend lifespan in aging mice
title_full_unstemmed Female XX sex chromosomes increase survival and extend lifespan in aging mice
title_short Female XX sex chromosomes increase survival and extend lifespan in aging mice
title_sort female xx sex chromosomes increase survival and extend lifespan in aging mice
topic Short Take
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351820/
https://www.ncbi.nlm.nih.gov/pubmed/30560587
http://dx.doi.org/10.1111/acel.12871
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AT dubaldenab femalexxsexchromosomesincreasesurvivalandextendlifespaninagingmice

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