RanGAP‐mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain

By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran‐mediated n...

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Detalles Bibliográficos
Autores principales: Wu, Di, Wu, Litao, An, Huanping, Bao, Hongcun, Guo, Pengfei, Zhang, Bei, Zheng, Huimei, Zhang, Fan, Ge, Wanzhong, Cai, Yu, Xi, Yongmei, Yang, Xiaohang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351831/
https://www.ncbi.nlm.nih.gov/pubmed/30549175
http://dx.doi.org/10.1111/acel.12854

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