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Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

During normal aging, innate immunity progresses to a chronic state. However, how oxidative stress and chronic neuroinflammation arise during aging remains unclear. In this study, we found that genetic ablation of cathepsin B (CatB) in mice significantly reduced the generation of reactive oxygen spec...

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Detalles Bibliográficos
Autores principales:	Ni, Junjun, Wu, Zhou, Stoka, Veronika, Meng, Jie, Hayashi, Yoshinori, Peters, Christoph, Qing, Hong, Turk, Vito, Nakanishi, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351837/ https://www.ncbi.nlm.nih.gov/pubmed/30575263 http://dx.doi.org/10.1111/acel.12856

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