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LncRNAs regulating stemness in aging
One of the most outstanding observations from next‐generation sequencing approaches was that only 1.5% of our genes code for proteins. The biggest part is transcribed but give rise to different families of RNAs without coding potential. The functional relevance of these abundant transcripts remains...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351848/ https://www.ncbi.nlm.nih.gov/pubmed/30456884 http://dx.doi.org/10.1111/acel.12870 |
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author | Sousa‐Franco, António Rebelo, Kenny da Rocha, Simão Teixeira Bernardes de Jesus, Bruno |
author_facet | Sousa‐Franco, António Rebelo, Kenny da Rocha, Simão Teixeira Bernardes de Jesus, Bruno |
author_sort | Sousa‐Franco, António |
collection | PubMed |
description | One of the most outstanding observations from next‐generation sequencing approaches was that only 1.5% of our genes code for proteins. The biggest part is transcribed but give rise to different families of RNAs without coding potential. The functional relevance of these abundant transcripts remains far from elucidated. Among them are the long non‐coding RNAs (lncRNAs), a relatively large and heterogeneous group of RNAs shown to be highly tissue‐specific, indicating a prominent role in processes controlling cellular identity. In particular, lncRNAs have been linked to both stemness properties and detrimental pathways regulating the aging process, being novel players in the intricate network guiding tissue homeostasis. Here, we summarize the up‐to‐date information on the role of lncRNAs that affect stemness and hence impact upon aging, highlighting the likelihood that lncRNAs may represent an unexploited reservoir of potential therapeutic targets for reprogramming applications and aging‐related diseases. |
format | Online Article Text |
id | pubmed-6351848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63518482019-02-07 LncRNAs regulating stemness in aging Sousa‐Franco, António Rebelo, Kenny da Rocha, Simão Teixeira Bernardes de Jesus, Bruno Aging Cell Reviews One of the most outstanding observations from next‐generation sequencing approaches was that only 1.5% of our genes code for proteins. The biggest part is transcribed but give rise to different families of RNAs without coding potential. The functional relevance of these abundant transcripts remains far from elucidated. Among them are the long non‐coding RNAs (lncRNAs), a relatively large and heterogeneous group of RNAs shown to be highly tissue‐specific, indicating a prominent role in processes controlling cellular identity. In particular, lncRNAs have been linked to both stemness properties and detrimental pathways regulating the aging process, being novel players in the intricate network guiding tissue homeostasis. Here, we summarize the up‐to‐date information on the role of lncRNAs that affect stemness and hence impact upon aging, highlighting the likelihood that lncRNAs may represent an unexploited reservoir of potential therapeutic targets for reprogramming applications and aging‐related diseases. John Wiley and Sons Inc. 2018-11-20 2019-02 /pmc/articles/PMC6351848/ /pubmed/30456884 http://dx.doi.org/10.1111/acel.12870 Text en © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Sousa‐Franco, António Rebelo, Kenny da Rocha, Simão Teixeira Bernardes de Jesus, Bruno LncRNAs regulating stemness in aging |
title | LncRNAs regulating stemness in aging |
title_full | LncRNAs regulating stemness in aging |
title_fullStr | LncRNAs regulating stemness in aging |
title_full_unstemmed | LncRNAs regulating stemness in aging |
title_short | LncRNAs regulating stemness in aging |
title_sort | lncrnas regulating stemness in aging |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351848/ https://www.ncbi.nlm.nih.gov/pubmed/30456884 http://dx.doi.org/10.1111/acel.12870 |
work_keys_str_mv | AT sousafrancoantonio lncrnasregulatingstemnessinaging AT rebelokenny lncrnasregulatingstemnessinaging AT darochasimaoteixeira lncrnasregulatingstemnessinaging AT bernardesdejesusbruno lncrnasregulatingstemnessinaging |