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The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania

Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Yea...

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Autores principales: Tataru, Ana-Liana, Furau, Gheorghe, Afilon, Jompan, Ionescu, Cringu, Dimitriu, Mihai, Bratu, Ovidiu Gabriel, Tit, Delia Mirela, Bungau, Simona, Furau, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351929/
https://www.ncbi.nlm.nih.gov/pubmed/30650666
http://dx.doi.org/10.3390/jcm8010096
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author Tataru, Ana-Liana
Furau, Gheorghe
Afilon, Jompan
Ionescu, Cringu
Dimitriu, Mihai
Bratu, Ovidiu Gabriel
Tit, Delia Mirela
Bungau, Simona
Furau, Cristian
author_facet Tataru, Ana-Liana
Furau, Gheorghe
Afilon, Jompan
Ionescu, Cringu
Dimitriu, Mihai
Bratu, Ovidiu Gabriel
Tit, Delia Mirela
Bungau, Simona
Furau, Cristian
author_sort Tataru, Ana-Liana
collection PubMed
description Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Year (DALY). Spatial analysis used Besag and Newell’s method for genital cancer distribution, prevalence considered Arad County patients records (2008–2017), and DALY was determined according to WHO methodology and GLOBOCAN 2013 data. Diagnosis was established by histopathological examination of diagnostic biopsies or tissues obtained by surgical procedures, followed by clinical staging. 1695 women were recorded with genital cancer. Of these, 14.9% of lesions were in situ (n = 252) and 74.20% of cases were recorded in stage III or IV (n = 1258) (p < 0.0001). Over 90% of cervical cancers were squamous cell carcinomas (n = 728), 33.76% of endometrial cancers were adenocarcinomas in situ (n = 131), 32.42% of ovarian cancers were serous adenocarcinomas (n = 131), and 70.58% of vulvar cancers were squamous cell carcinomas (n = 48) (p < 0.0001). DALY/1000 was 67.2 for genital cancers and 33 for cervical cancers. From the point of view of Romanian women, cervical cancer remains one of the major problems that need to be dealt with and access to optimal treatment proves to be extremely limited.
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spelling pubmed-63519292019-02-01 The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania Tataru, Ana-Liana Furau, Gheorghe Afilon, Jompan Ionescu, Cringu Dimitriu, Mihai Bratu, Ovidiu Gabriel Tit, Delia Mirela Bungau, Simona Furau, Cristian J Clin Med Article Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Year (DALY). Spatial analysis used Besag and Newell’s method for genital cancer distribution, prevalence considered Arad County patients records (2008–2017), and DALY was determined according to WHO methodology and GLOBOCAN 2013 data. Diagnosis was established by histopathological examination of diagnostic biopsies or tissues obtained by surgical procedures, followed by clinical staging. 1695 women were recorded with genital cancer. Of these, 14.9% of lesions were in situ (n = 252) and 74.20% of cases were recorded in stage III or IV (n = 1258) (p < 0.0001). Over 90% of cervical cancers were squamous cell carcinomas (n = 728), 33.76% of endometrial cancers were adenocarcinomas in situ (n = 131), 32.42% of ovarian cancers were serous adenocarcinomas (n = 131), and 70.58% of vulvar cancers were squamous cell carcinomas (n = 48) (p < 0.0001). DALY/1000 was 67.2 for genital cancers and 33 for cervical cancers. From the point of view of Romanian women, cervical cancer remains one of the major problems that need to be dealt with and access to optimal treatment proves to be extremely limited. MDPI 2019-01-15 /pmc/articles/PMC6351929/ /pubmed/30650666 http://dx.doi.org/10.3390/jcm8010096 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tataru, Ana-Liana
Furau, Gheorghe
Afilon, Jompan
Ionescu, Cringu
Dimitriu, Mihai
Bratu, Ovidiu Gabriel
Tit, Delia Mirela
Bungau, Simona
Furau, Cristian
The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title_full The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title_fullStr The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title_full_unstemmed The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title_short The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania
title_sort situation of cervical cancers in the context of female genital cancer clustering and burden of disease in arad county, romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351929/
https://www.ncbi.nlm.nih.gov/pubmed/30650666
http://dx.doi.org/10.3390/jcm8010096
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