Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influ...

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Autores principales: Skowronski, Danuta M, Leir, Siobhan, Sabaiduc, Suzana, Murti, Michelle, Dickinson, James A, Olsha, Romy, Gubbay, Jonathan B, Croxen, Matthew A, Charest, Hugues, Chan, Tracy, Bastien, Nathalie, Li, Yan, Krajden, Mel, De Serres, Gaston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351998/
https://www.ncbi.nlm.nih.gov/pubmed/30696523
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.4.1900055
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author Skowronski, Danuta M
Leir, Siobhan
Sabaiduc, Suzana
Murti, Michelle
Dickinson, James A
Olsha, Romy
Gubbay, Jonathan B
Croxen, Matthew A
Charest, Hugues
Chan, Tracy
Bastien, Nathalie
Li, Yan
Krajden, Mel
De Serres, Gaston
author_facet Skowronski, Danuta M
Leir, Siobhan
Sabaiduc, Suzana
Murti, Michelle
Dickinson, James A
Olsha, Romy
Gubbay, Jonathan B
Croxen, Matthew A
Charest, Hugues
Chan, Tracy
Bastien, Nathalie
Li, Yan
Krajden, Mel
De Serres, Gaston
author_sort Skowronski, Danuta M
collection PubMed
description Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant.
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spelling pubmed-63519982019-02-15 Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019 Skowronski, Danuta M Leir, Siobhan Sabaiduc, Suzana Murti, Michelle Dickinson, James A Olsha, Romy Gubbay, Jonathan B Croxen, Matthew A Charest, Hugues Chan, Tracy Bastien, Nathalie Li, Yan Krajden, Mel De Serres, Gaston Euro Surveill Rapid Communication Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant. European Centre for Disease Prevention and Control (ECDC) 2019-01-24 /pmc/articles/PMC6351998/ /pubmed/30696523 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.4.1900055 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Skowronski, Danuta M
Leir, Siobhan
Sabaiduc, Suzana
Murti, Michelle
Dickinson, James A
Olsha, Romy
Gubbay, Jonathan B
Croxen, Matthew A
Charest, Hugues
Chan, Tracy
Bastien, Nathalie
Li, Yan
Krajden, Mel
De Serres, Gaston
Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title_full Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title_fullStr Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title_full_unstemmed Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title_short Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
title_sort interim estimates of 2018/19 vaccine effectiveness against influenza a(h1n1)pdm09, canada, january 2019
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351998/
https://www.ncbi.nlm.nih.gov/pubmed/30696523
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.4.1900055
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