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Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families

Psoriasis is considered to result from the interaction of genetic factors and environmental exposure. The evidence for familial aggregation in psoriasis has been reported but population-based studies related to the magnitude of genetic contribution to psoriasis are rare. This study aimed to evaluate...

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Autores principales: Huang, Yu-Huei, Kuo, Chang-Fu, Huang, Lu-Hsiang, Hsieh, Mei-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352137/
https://www.ncbi.nlm.nih.gov/pubmed/30669308
http://dx.doi.org/10.3390/jcm8010115
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author Huang, Yu-Huei
Kuo, Chang-Fu
Huang, Lu-Hsiang
Hsieh, Mei-Yun
author_facet Huang, Yu-Huei
Kuo, Chang-Fu
Huang, Lu-Hsiang
Hsieh, Mei-Yun
author_sort Huang, Yu-Huei
collection PubMed
description Psoriasis is considered to result from the interaction of genetic factors and environmental exposure. The evidence for familial aggregation in psoriasis has been reported but population-based studies related to the magnitude of genetic contribution to psoriasis are rare. This study aimed to evaluate the relative risks of psoriasis in individuals with affected relatives and to calculate the proportion of genetic, shared, and non-shared environmental factors contributing to psoriasis. The study cohort included 69,828 patients diagnosed with psoriasis enrolled in National health Insurance in 2010. The adjusted relative risks (RR) for individuals with an affected first-degree relative and affected second-degree relative were 5.50 (95% CI (Confidence Interval), 5.19–5.82) and 2.54 (95% CI, 2.08–3.12) respectively. For those who have affected first-degree relatives, their RR was 1.45 (95% CI, 1.17–1.79) for Sjogren’s syndrome and 1.94 (95% CI, 1.15–3.27) for systemic sclerosis. This nationwide study ascertains that family history of psoriasis is a risk factor for psoriasis. Individuals with relatives affected by psoriasis have higher risks of developing some autoimmune diseases.
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spelling pubmed-63521372019-02-01 Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families Huang, Yu-Huei Kuo, Chang-Fu Huang, Lu-Hsiang Hsieh, Mei-Yun J Clin Med Article Psoriasis is considered to result from the interaction of genetic factors and environmental exposure. The evidence for familial aggregation in psoriasis has been reported but population-based studies related to the magnitude of genetic contribution to psoriasis are rare. This study aimed to evaluate the relative risks of psoriasis in individuals with affected relatives and to calculate the proportion of genetic, shared, and non-shared environmental factors contributing to psoriasis. The study cohort included 69,828 patients diagnosed with psoriasis enrolled in National health Insurance in 2010. The adjusted relative risks (RR) for individuals with an affected first-degree relative and affected second-degree relative were 5.50 (95% CI (Confidence Interval), 5.19–5.82) and 2.54 (95% CI, 2.08–3.12) respectively. For those who have affected first-degree relatives, their RR was 1.45 (95% CI, 1.17–1.79) for Sjogren’s syndrome and 1.94 (95% CI, 1.15–3.27) for systemic sclerosis. This nationwide study ascertains that family history of psoriasis is a risk factor for psoriasis. Individuals with relatives affected by psoriasis have higher risks of developing some autoimmune diseases. MDPI 2019-01-18 /pmc/articles/PMC6352137/ /pubmed/30669308 http://dx.doi.org/10.3390/jcm8010115 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yu-Huei
Kuo, Chang-Fu
Huang, Lu-Hsiang
Hsieh, Mei-Yun
Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title_full Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title_fullStr Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title_full_unstemmed Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title_short Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families
title_sort familial aggregation of psoriasis and co-aggregation of autoimmune diseases in affected families
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352137/
https://www.ncbi.nlm.nih.gov/pubmed/30669308
http://dx.doi.org/10.3390/jcm8010115
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