Cargando…

Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination

A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated...

Descripción completa

Detalles Bibliográficos
Autores principales: Zamora, Elisabet, Seder-Colomina, Elena, Holgado, Susana, Quirant-Sanchez, Bibiana, Mate, José Luis, Martínez-Cáceres, Eva M., Casafont, Ivette, Bayés-Genís, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352216/
https://www.ncbi.nlm.nih.gov/pubmed/30583602
http://dx.doi.org/10.3390/jcm8010020
Descripción
Sumario:A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination.