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Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination

A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated...

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Autores principales: Zamora, Elisabet, Seder-Colomina, Elena, Holgado, Susana, Quirant-Sanchez, Bibiana, Mate, José Luis, Martínez-Cáceres, Eva M., Casafont, Ivette, Bayés-Genís, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352216/
https://www.ncbi.nlm.nih.gov/pubmed/30583602
http://dx.doi.org/10.3390/jcm8010020
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author Zamora, Elisabet
Seder-Colomina, Elena
Holgado, Susana
Quirant-Sanchez, Bibiana
Mate, José Luis
Martínez-Cáceres, Eva M.
Casafont, Ivette
Bayés-Genís, Antoni
author_facet Zamora, Elisabet
Seder-Colomina, Elena
Holgado, Susana
Quirant-Sanchez, Bibiana
Mate, José Luis
Martínez-Cáceres, Eva M.
Casafont, Ivette
Bayés-Genís, Antoni
author_sort Zamora, Elisabet
collection PubMed
description A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination.
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spelling pubmed-63522162019-02-01 Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination Zamora, Elisabet Seder-Colomina, Elena Holgado, Susana Quirant-Sanchez, Bibiana Mate, José Luis Martínez-Cáceres, Eva M. Casafont, Ivette Bayés-Genís, Antoni J Clin Med Case Report A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. MDPI 2018-12-23 /pmc/articles/PMC6352216/ /pubmed/30583602 http://dx.doi.org/10.3390/jcm8010020 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zamora, Elisabet
Seder-Colomina, Elena
Holgado, Susana
Quirant-Sanchez, Bibiana
Mate, José Luis
Martínez-Cáceres, Eva M.
Casafont, Ivette
Bayés-Genís, Antoni
Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title_full Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title_fullStr Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title_full_unstemmed Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title_short Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
title_sort heart–lung–muscle anti-sae syndrome: an atypical severe combination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352216/
https://www.ncbi.nlm.nih.gov/pubmed/30583602
http://dx.doi.org/10.3390/jcm8010020
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