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Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352216/ https://www.ncbi.nlm.nih.gov/pubmed/30583602 http://dx.doi.org/10.3390/jcm8010020 |
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author | Zamora, Elisabet Seder-Colomina, Elena Holgado, Susana Quirant-Sanchez, Bibiana Mate, José Luis Martínez-Cáceres, Eva M. Casafont, Ivette Bayés-Genís, Antoni |
author_facet | Zamora, Elisabet Seder-Colomina, Elena Holgado, Susana Quirant-Sanchez, Bibiana Mate, José Luis Martínez-Cáceres, Eva M. Casafont, Ivette Bayés-Genís, Antoni |
author_sort | Zamora, Elisabet |
collection | PubMed |
description | A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. |
format | Online Article Text |
id | pubmed-6352216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63522162019-02-01 Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination Zamora, Elisabet Seder-Colomina, Elena Holgado, Susana Quirant-Sanchez, Bibiana Mate, José Luis Martínez-Cáceres, Eva M. Casafont, Ivette Bayés-Genís, Antoni J Clin Med Case Report A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. MDPI 2018-12-23 /pmc/articles/PMC6352216/ /pubmed/30583602 http://dx.doi.org/10.3390/jcm8010020 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Zamora, Elisabet Seder-Colomina, Elena Holgado, Susana Quirant-Sanchez, Bibiana Mate, José Luis Martínez-Cáceres, Eva M. Casafont, Ivette Bayés-Genís, Antoni Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title | Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title_full | Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title_fullStr | Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title_full_unstemmed | Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title_short | Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination |
title_sort | heart–lung–muscle anti-sae syndrome: an atypical severe combination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352216/ https://www.ncbi.nlm.nih.gov/pubmed/30583602 http://dx.doi.org/10.3390/jcm8010020 |
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