Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment

Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection...

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Detalles Bibliográficos
Autores principales: Van Arendonk, Kyle J., Chung, Dai H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352222/
https://www.ncbi.nlm.nih.gov/pubmed/30658459
http://dx.doi.org/10.3390/children6010012
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author Van Arendonk, Kyle J.
Chung, Dai H.
author_facet Van Arendonk, Kyle J.
Chung, Dai H.
author_sort Van Arendonk, Kyle J.
collection PubMed
description Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection in neuroblastoma is also reviewed, including the indications and timing of surgery within the greater treatment plan.
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spelling pubmed-63522222019-02-01 Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment Van Arendonk, Kyle J. Chung, Dai H. Children (Basel) Review Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection in neuroblastoma is also reviewed, including the indications and timing of surgery within the greater treatment plan. MDPI 2019-01-17 /pmc/articles/PMC6352222/ /pubmed/30658459 http://dx.doi.org/10.3390/children6010012 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Van Arendonk, Kyle J.
Chung, Dai H.
Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title_full Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title_fullStr Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title_full_unstemmed Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title_short Neuroblastoma: Tumor Biology and Its Implications for Staging and Treatment
title_sort neuroblastoma: tumor biology and its implications for staging and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352222/
https://www.ncbi.nlm.nih.gov/pubmed/30658459
http://dx.doi.org/10.3390/children6010012
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