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Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study

Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracte...

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Autores principales: Shin, Tae Gun, Kim, Youn-Jung, Ryoo, Seung Mok, Hwang, Sung Yeon, Jo, Ik Joon, Chung, Sung Phil, Choi, Sung-Hyuk, Suh, Gil Joon, Kim, Won Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352246/
https://www.ncbi.nlm.nih.gov/pubmed/30654592
http://dx.doi.org/10.3390/jcm8010102
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author Shin, Tae Gun
Kim, Youn-Jung
Ryoo, Seung Mok
Hwang, Sung Yeon
Jo, Ik Joon
Chung, Sung Phil
Choi, Sung-Hyuk
Suh, Gil Joon
Kim, Won Young
author_facet Shin, Tae Gun
Kim, Youn-Jung
Ryoo, Seung Mok
Hwang, Sung Yeon
Jo, Ik Joon
Chung, Sung Phil
Choi, Sung-Hyuk
Suh, Gil Joon
Kim, Won Young
author_sort Shin, Tae Gun
collection PubMed
description Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society’s prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and control patients from October 2015 through June 2017 (n = 915) using propensity score matching. Results: The 28-day (18.3% vs. 17.5%; p = 0.76) and in-hospital (16.6% vs. 18.3%; p = 0.55) mortality rates did not differ between treatment and control groups, nor did 28-day (18.5% vs. 17.5%; p = 0.84) and in-hospital (16.7% vs. 18.4%; p = 0.54) mortality rates after matching. In the subgroup analysis, treatment was associated with lower in-hospital mortality rates in patients with albumin <3.0 mg/dL or a Sequential Organ Failure Assessment (SOFA) score >10. Conclusion: Early vitamin C and thiamine administration in patients with septic shock did not improve survival; however, administration could benefit conditions that are more severe, such as hypoalbuminemia or severe organ failure.
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spelling pubmed-63522462019-02-01 Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study Shin, Tae Gun Kim, Youn-Jung Ryoo, Seung Mok Hwang, Sung Yeon Jo, Ik Joon Chung, Sung Phil Choi, Sung-Hyuk Suh, Gil Joon Kim, Won Young J Clin Med Article Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society’s prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and control patients from October 2015 through June 2017 (n = 915) using propensity score matching. Results: The 28-day (18.3% vs. 17.5%; p = 0.76) and in-hospital (16.6% vs. 18.3%; p = 0.55) mortality rates did not differ between treatment and control groups, nor did 28-day (18.5% vs. 17.5%; p = 0.84) and in-hospital (16.7% vs. 18.4%; p = 0.54) mortality rates after matching. In the subgroup analysis, treatment was associated with lower in-hospital mortality rates in patients with albumin <3.0 mg/dL or a Sequential Organ Failure Assessment (SOFA) score >10. Conclusion: Early vitamin C and thiamine administration in patients with septic shock did not improve survival; however, administration could benefit conditions that are more severe, such as hypoalbuminemia or severe organ failure. MDPI 2019-01-16 /pmc/articles/PMC6352246/ /pubmed/30654592 http://dx.doi.org/10.3390/jcm8010102 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shin, Tae Gun
Kim, Youn-Jung
Ryoo, Seung Mok
Hwang, Sung Yeon
Jo, Ik Joon
Chung, Sung Phil
Choi, Sung-Hyuk
Suh, Gil Joon
Kim, Won Young
Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title_full Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title_fullStr Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title_full_unstemmed Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title_short Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
title_sort early vitamin c and thiamine administration to patients with septic shock in emergency departments: propensity score-based analysis of a before-and-after cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352246/
https://www.ncbi.nlm.nih.gov/pubmed/30654592
http://dx.doi.org/10.3390/jcm8010102
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