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Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound

Background: Atherosclerosis is a systemic multifocal disease with a preference for the branching points of the arteries. In this study, we quantitatively measured carotid and femoral plaque volume in subjects with cardiovascular risk factors (CVRF) and/or established atherosclerotic disease using a...

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Autores principales: Noflatscher, Maria, Schreinlechner, Michael, Sommer, Philip, Kerschbaum, Julia, Berggren, Katharina, Theurl, Markus, Kirchmair, Rudolf, Marschang, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352255/
https://www.ncbi.nlm.nih.gov/pubmed/30602707
http://dx.doi.org/10.3390/jcm8010032
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author Noflatscher, Maria
Schreinlechner, Michael
Sommer, Philip
Kerschbaum, Julia
Berggren, Katharina
Theurl, Markus
Kirchmair, Rudolf
Marschang, Peter
author_facet Noflatscher, Maria
Schreinlechner, Michael
Sommer, Philip
Kerschbaum, Julia
Berggren, Katharina
Theurl, Markus
Kirchmair, Rudolf
Marschang, Peter
author_sort Noflatscher, Maria
collection PubMed
description Background: Atherosclerosis is a systemic multifocal disease with a preference for the branching points of the arteries. In this study, we quantitatively measured carotid and femoral plaque volume in subjects with cardiovascular risk factors (CVRF) and/or established atherosclerotic disease using a 3D ultrasound technique. Methods: In this prospective, single-centre study, we included 404 patients (median age 64; 56.9% men) with at least one CVRF or established cardiovascular disease. Plaque volume was measured using 3D ultrasound equipped with an automated software. Results: We found a strong correlation of plaque volume with CVRF and the number of vascular beds involved. The strongest associations with total and femoral plaque volume were noted for smoking, hypertension, age, as well as for the presence of peripheral arterial occlusive disease (p < 0.05). Carotid plaque volume was best predicted by hyperlipidaemia, hypertension, age, as well as the presence of cerebrovascular disease and coronary artery disease (p < 0.05). Conclusion: We conclude that smoking appears to be associated with total and femoral plaque volume, whereas hyperlipidaemia seems to be associated with carotid plaque volume. Measurement of 3D plaque volume is a practical and reproducible technique with the potential to become an additional screening tool in cardiovascular risk stratification.
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spelling pubmed-63522552019-02-01 Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound Noflatscher, Maria Schreinlechner, Michael Sommer, Philip Kerschbaum, Julia Berggren, Katharina Theurl, Markus Kirchmair, Rudolf Marschang, Peter J Clin Med Article Background: Atherosclerosis is a systemic multifocal disease with a preference for the branching points of the arteries. In this study, we quantitatively measured carotid and femoral plaque volume in subjects with cardiovascular risk factors (CVRF) and/or established atherosclerotic disease using a 3D ultrasound technique. Methods: In this prospective, single-centre study, we included 404 patients (median age 64; 56.9% men) with at least one CVRF or established cardiovascular disease. Plaque volume was measured using 3D ultrasound equipped with an automated software. Results: We found a strong correlation of plaque volume with CVRF and the number of vascular beds involved. The strongest associations with total and femoral plaque volume were noted for smoking, hypertension, age, as well as for the presence of peripheral arterial occlusive disease (p < 0.05). Carotid plaque volume was best predicted by hyperlipidaemia, hypertension, age, as well as the presence of cerebrovascular disease and coronary artery disease (p < 0.05). Conclusion: We conclude that smoking appears to be associated with total and femoral plaque volume, whereas hyperlipidaemia seems to be associated with carotid plaque volume. Measurement of 3D plaque volume is a practical and reproducible technique with the potential to become an additional screening tool in cardiovascular risk stratification. MDPI 2018-12-31 /pmc/articles/PMC6352255/ /pubmed/30602707 http://dx.doi.org/10.3390/jcm8010032 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noflatscher, Maria
Schreinlechner, Michael
Sommer, Philip
Kerschbaum, Julia
Berggren, Katharina
Theurl, Markus
Kirchmair, Rudolf
Marschang, Peter
Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title_full Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title_fullStr Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title_full_unstemmed Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title_short Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound
title_sort influence of traditional cardiovascular risk factors on carotid and femoral atherosclerotic plaque volume as measured by three-dimensional ultrasound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352255/
https://www.ncbi.nlm.nih.gov/pubmed/30602707
http://dx.doi.org/10.3390/jcm8010032
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