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The growing role of precision and personalized medicine for cancer treatment

Cancer is a devastating disease that takes the lives of hundreds of thousands of people every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only a subset of the patient population. Tumors can have different underlying genetic causes and...

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Autores principales: Krzyszczyk, Paulina, Acevedo, Alison, Davidoff, Erika J., Timmins, Lauren M., Marrero-Berrios, Ileana, Patel, Misaal, White, Corina, Lowe, Christopher, Sherba, Joseph J., Hartmanshenn, Clara, O’Neill, Kate M., Balter, Max L., Fritz, Zachary R., Androulakis, Ioannis P., Schloss, Rene S., Yarmush, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352312/
https://www.ncbi.nlm.nih.gov/pubmed/30713991
http://dx.doi.org/10.1142/S2339547818300020
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author Krzyszczyk, Paulina
Acevedo, Alison
Davidoff, Erika J.
Timmins, Lauren M.
Marrero-Berrios, Ileana
Patel, Misaal
White, Corina
Lowe, Christopher
Sherba, Joseph J.
Hartmanshenn, Clara
O’Neill, Kate M.
Balter, Max L.
Fritz, Zachary R.
Androulakis, Ioannis P.
Schloss, Rene S.
Yarmush, Martin L.
author_facet Krzyszczyk, Paulina
Acevedo, Alison
Davidoff, Erika J.
Timmins, Lauren M.
Marrero-Berrios, Ileana
Patel, Misaal
White, Corina
Lowe, Christopher
Sherba, Joseph J.
Hartmanshenn, Clara
O’Neill, Kate M.
Balter, Max L.
Fritz, Zachary R.
Androulakis, Ioannis P.
Schloss, Rene S.
Yarmush, Martin L.
author_sort Krzyszczyk, Paulina
collection PubMed
description Cancer is a devastating disease that takes the lives of hundreds of thousands of people every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only a subset of the patient population. Tumors can have different underlying genetic causes and may express different proteins in one patient versus another. This inherent variability of cancer lends itself to the growing field of precision and personalized medicine (PPM). There are many ongoing efforts to acquire PPM data in order to characterize molecular differences between tumors. Some PPM products are already available to link these differences to an effective drug. It is clear that PPM cancer treatments can result in immense patient benefits, and companies and regulatory agencies have begun to recognize this. However, broader changes to the healthcare and insurance systems must be addressed if PPM is to become part of standard cancer care.
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spelling pubmed-63523122019-01-30 The growing role of precision and personalized medicine for cancer treatment Krzyszczyk, Paulina Acevedo, Alison Davidoff, Erika J. Timmins, Lauren M. Marrero-Berrios, Ileana Patel, Misaal White, Corina Lowe, Christopher Sherba, Joseph J. Hartmanshenn, Clara O’Neill, Kate M. Balter, Max L. Fritz, Zachary R. Androulakis, Ioannis P. Schloss, Rene S. Yarmush, Martin L. Technology (Singap World Sci) Article Cancer is a devastating disease that takes the lives of hundreds of thousands of people every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only a subset of the patient population. Tumors can have different underlying genetic causes and may express different proteins in one patient versus another. This inherent variability of cancer lends itself to the growing field of precision and personalized medicine (PPM). There are many ongoing efforts to acquire PPM data in order to characterize molecular differences between tumors. Some PPM products are already available to link these differences to an effective drug. It is clear that PPM cancer treatments can result in immense patient benefits, and companies and regulatory agencies have begun to recognize this. However, broader changes to the healthcare and insurance systems must be addressed if PPM is to become part of standard cancer care. 2019-01-11 2018 /pmc/articles/PMC6352312/ /pubmed/30713991 http://dx.doi.org/10.1142/S2339547818300020 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited.
spellingShingle Article
Krzyszczyk, Paulina
Acevedo, Alison
Davidoff, Erika J.
Timmins, Lauren M.
Marrero-Berrios, Ileana
Patel, Misaal
White, Corina
Lowe, Christopher
Sherba, Joseph J.
Hartmanshenn, Clara
O’Neill, Kate M.
Balter, Max L.
Fritz, Zachary R.
Androulakis, Ioannis P.
Schloss, Rene S.
Yarmush, Martin L.
The growing role of precision and personalized medicine for cancer treatment
title The growing role of precision and personalized medicine for cancer treatment
title_full The growing role of precision and personalized medicine for cancer treatment
title_fullStr The growing role of precision and personalized medicine for cancer treatment
title_full_unstemmed The growing role of precision and personalized medicine for cancer treatment
title_short The growing role of precision and personalized medicine for cancer treatment
title_sort growing role of precision and personalized medicine for cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352312/
https://www.ncbi.nlm.nih.gov/pubmed/30713991
http://dx.doi.org/10.1142/S2339547818300020
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