Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses

OBJECTIVE: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for cl...

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Detalles Bibliográficos
Autores principales: Chen, Bo, Vousden, Katherine A, Naiman, Brian, Turman, Sean, Sun, Hong, Wang, Shu, Vinall, Lisa M K, Kemp, Benjamin P, Kasturiangan, Srinath, Rees, D Gareth, Grant, Ethan, Hinrichs, Mary Jane, Eck, Steven, DiGiandomenico, Antonio, Jack Borrok, M, Ly, Neang, Xiong, Ximing, Gonzalez, Carlos, Morehouse, Christopher, Wang, Yue, Zhou, Yebin, Cann, Jennifer, Zhao, Weiguang, Koelkebeck, Holly, Okubo, Koshu, Mayadas, Tanya N, Howe, David, Griffiths, Janet, Kolbeck, Roland, Herbst, Ronald, Sims, Gary P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Connective Tissue Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://www.ncbi.nlm.nih.gov/pubmed/30459279
http://dx.doi.org/10.1136/annrheumdis-2018-213523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://www.ncbi.nlm.nih.gov/pubmed/30459279
http://dx.doi.org/10.1136/annrheumdis-2018-213523

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