Cargando…

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

BACKGROUND: Adenylate kinase 4 (AK4) has been identified as a biomarker of metastasis in lung cancer. However, the impacts of AK4 on metabolic genes and its translational value for drug repositioning remain unclear. METHODS: Ingenuity upstream analyses were used to identify potential transcription f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jan, Yi-Hua, Lai, Tsung-Ching, Yang, Chih-Jen, Lin, Yuan-Feng, Huang, Ming-Shyan, Hsiao, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352453/ https://www.ncbi.nlm.nih.gov/pubmed/30696468 http://dx.doi.org/10.1186/s13045-019-0698-5

Ejemplares similares

A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma
por: Jan, Yi-Hua, et al.
Publicado: (2019)

Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages
por: Chin, Wei-Yao, et al.
Publicado: (2021)

Water content, adenylate kinase, and mitochondria drive adenylate balance in dehydrating and imbibing seeds
por: Raveneau, Marie-Paule, et al.
Publicado: (2017)

Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma
por: Liu, Huibin, et al.
Publicado: (2019)

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
por: Casillas, Andrea L., et al.
Publicado: (2021)

Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma
por: Ahn, Bokyung, et al.
Publicado: (2021)

ASC modulates HIF-1α stability and induces cell mobility in OSCC
por: Wu, Chi-Sheng, et al.
Publicado: (2020)

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
por: Chou, Chih-Chien, et al.
Publicado: (2015)

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1
por: Mayro, Benjamin, et al.
Publicado: (2023)

Localization of Adenylate Kinase 4 in Mouse Tissues
por: Miyoshi, Keiko, et al.
Publicado: (2009)

Correlated Inter-Domain Motions in Adenylate Kinase
por: Esteban-Martín, Santiago, et al.
Publicado: (2014)

The energy landscape of adenylate kinase during catalysis
por: Kerns, S. Jordan, et al.
Publicado: (2015)

Adenylate Kinase and Metabolic Signaling in Cancer Cells
por: Klepinin, Aleksandr, et al.
Publicado: (2020)

Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways
por: Wujak, Magdalena, et al.
Publicado: (2021)

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
por: Hsiao, Huey-Wen, et al.
Publicado: (2015)

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase
por: Scheerer, David, et al.
Publicado: (2023)

LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α
por: Xu, Linguo, et al.
Publicado: (2020)

Protein kinase C sensitizes olfactory adenylate cyclase
Publicado: (1993)

Conformational Dynamics of a Ligand-Free Adenylate Kinase
por: Song, Hyun Deok, et al.
Publicado: (2013)

Coupled ATPase-adenylate kinase activity in ABC transporters
por: Kaur, Hundeep, et al.
Publicado: (2016)

Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis
por: Chiou, Jean, et al.
Publicado: (2019)

Lung Adenocarcinoma Transcriptomic Analysis Predicts Adenylate Kinase Signatures Contributing to Tumor Progression and Negative Patient Prognosis
por: Chacon-Barahona, Jonathan A., et al.
Publicado: (2021)

Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4
por: Fujisawa, Koichi, et al.
Publicado: (2016)

HIF1α or mitophagy: which drives cardiomyocyte differentiation?
por: Villarejo-Zori, Beatriz, et al.
Publicado: (2020)

The Diverse Roles of TAO Kinases in Health and Diseases
por: Fang, Chih-Yeu, et al.
Publicado: (2020)

LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma
por: Song, Kun, et al.
Publicado: (2021)

The role of the C8 proton of ATP in the catalysis of shikimate kinase and adenylate kinase
por: Kenyon, Colin P, et al.
Publicado: (2012)

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease
por: Lackey, Lela, et al.
Publicado: (2021)

Structural and mutational analyses of psychrophilic and mesophilic adenylate kinases highlight the role of hydrophobic interactions in protein thermal stability
por: Moon, Sojin, et al.
Publicado: (2019)

Regulation of HIF-1α stability by lysine methylation
por: Baek, Sung Hee, et al.
Publicado: (2016)

Stabilization of HIF-2α impacts pancreas growth
por: Flores-Martínez, Alvaro, et al.
Publicado: (2018)

HIF1α stabilization in hypoxia is not oxidant-initiated
por: Kumar, Amit, et al.
Publicado: (2021)

Interconversion of Functional Motions between Mesophilic and Thermophilic Adenylate Kinases
por: Daily, Michael D., et al.
Publicado: (2011)

RNA Mimicry by the Fap7 Adenylate Kinase in Ribosome Biogenesis
por: Loc'h, Jérôme, et al.
Publicado: (2014)

Linkage between Fitness of Yeast Cells and Adenylate Kinase Catalysis
por: Tükenmez, Hasan, et al.
Publicado: (2016)

Tracking the ATP-binding response in adenylate kinase in real time
por: Orädd, Fredrik, et al.
Publicado: (2021)

Integration of Adenylate Kinase 1 with Its Peptide Conformational Imprint
por: Wu, Cheng-Hsin, et al.
Publicado: (2022)

Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase
por: Lu, Jiajun, et al.
Publicado: (2022)

Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis
por: Lin, Yu-Wei, et al.
Publicado: (2019)

Adenylate kinase potentiates the capsular polysaccharide by modulating Cps2D in Streptococcus pneumoniae D39
por: Ghosh, Prachetash, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i14sjvslhij1imkmkgnnq6brk0