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Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends
During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352590/ https://www.ncbi.nlm.nih.gov/pubmed/30632512 http://dx.doi.org/10.4103/1673-5374.247475 |
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author | Kou, Yu-Hui Yu, You-Lai Zhang, Ya-Jun Han, Na Yin, Xiao-Feng Yuan, Yu-Song Yu, Fei Zhang, Dian-Ying Zhang, Pei-Xun Jiang, Bao-Guo |
author_facet | Kou, Yu-Hui Yu, You-Lai Zhang, Ya-Jun Han, Na Yin, Xiao-Feng Yuan, Yu-Song Yu, Fei Zhang, Dian-Ying Zhang, Pei-Xun Jiang, Bao-Guo |
author_sort | Kou, Yu-Hui |
collection | PubMed |
description | During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the bio-sleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves. |
format | Online Article Text |
id | pubmed-6352590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63525902019-04-01 Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends Kou, Yu-Hui Yu, You-Lai Zhang, Ya-Jun Han, Na Yin, Xiao-Feng Yuan, Yu-Song Yu, Fei Zhang, Dian-Ying Zhang, Pei-Xun Jiang, Bao-Guo Neural Regen Res Research Article During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the bio-sleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves. Medknow Publications & Media Pvt Ltd 2019-04 /pmc/articles/PMC6352590/ /pubmed/30632512 http://dx.doi.org/10.4103/1673-5374.247475 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Kou, Yu-Hui Yu, You-Lai Zhang, Ya-Jun Han, Na Yin, Xiao-Feng Yuan, Yu-Song Yu, Fei Zhang, Dian-Ying Zhang, Pei-Xun Jiang, Bao-Guo Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title_full | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title_fullStr | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title_full_unstemmed | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title_short | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
title_sort | repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352590/ https://www.ncbi.nlm.nih.gov/pubmed/30632512 http://dx.doi.org/10.4103/1673-5374.247475 |
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