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Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

Parkinson’s disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have bee...

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Autores principales: Benzagmout, Mohammed, Boujraf, Saïd, Alami, Badreeddine, Amadou, Hassane Ali, El Hamdaoui, Halima, Bennani, Amine, Jaafari, Mounir, Rammouz, Ismail, Maaroufi, Mustapha, Magoul, Rabia, Boussaoud, Driss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352597/
https://www.ncbi.nlm.nih.gov/pubmed/30632507
http://dx.doi.org/10.4103/1673-5374.247470
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author Benzagmout, Mohammed
Boujraf, Saïd
Alami, Badreeddine
Amadou, Hassane Ali
El Hamdaoui, Halima
Bennani, Amine
Jaafari, Mounir
Rammouz, Ismail
Maaroufi, Mustapha
Magoul, Rabia
Boussaoud, Driss
author_facet Benzagmout, Mohammed
Boujraf, Saïd
Alami, Badreeddine
Amadou, Hassane Ali
El Hamdaoui, Halima
Bennani, Amine
Jaafari, Mounir
Rammouz, Ismail
Maaroufi, Mustapha
Magoul, Rabia
Boussaoud, Driss
author_sort Benzagmout, Mohammed
collection PubMed
description Parkinson’s disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson’s disease and to explore whether there are differences between recognition of different types of emotions in Parkinson’s disease. We examined 18 patients with Parkinson’s disease (8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson’s disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson’s disease.
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spelling pubmed-63525972019-04-01 Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study Benzagmout, Mohammed Boujraf, Saïd Alami, Badreeddine Amadou, Hassane Ali El Hamdaoui, Halima Bennani, Amine Jaafari, Mounir Rammouz, Ismail Maaroufi, Mustapha Magoul, Rabia Boussaoud, Driss Neural Regen Res Research Article Parkinson’s disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson’s disease and to explore whether there are differences between recognition of different types of emotions in Parkinson’s disease. We examined 18 patients with Parkinson’s disease (8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson’s disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson’s disease. Medknow Publications & Media Pvt Ltd 2019-04 /pmc/articles/PMC6352597/ /pubmed/30632507 http://dx.doi.org/10.4103/1673-5374.247470 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Benzagmout, Mohammed
Boujraf, Saïd
Alami, Badreeddine
Amadou, Hassane Ali
El Hamdaoui, Halima
Bennani, Amine
Jaafari, Mounir
Rammouz, Ismail
Maaroufi, Mustapha
Magoul, Rabia
Boussaoud, Driss
Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title_full Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title_fullStr Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title_full_unstemmed Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title_short Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
title_sort emotion processing in parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352597/
https://www.ncbi.nlm.nih.gov/pubmed/30632507
http://dx.doi.org/10.4103/1673-5374.247470
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