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Biomechanical Modeling of Human Skin Tissue Surrogates
Surrogates, which precisely simulate nonlinear mechanical properties of the human skin at different body sites, would be indispensable for biomechanical testing applications, such as estimating the accurate load response of skin implants and prosthetics to study the biomechanics of static and dynami...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352690/ https://www.ncbi.nlm.nih.gov/pubmed/31105240 http://dx.doi.org/10.3390/biomimetics3030018 |
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author | Chanda, Arnab |
author_facet | Chanda, Arnab |
author_sort | Chanda, Arnab |
collection | PubMed |
description | Surrogates, which precisely simulate nonlinear mechanical properties of the human skin at different body sites, would be indispensable for biomechanical testing applications, such as estimating the accurate load response of skin implants and prosthetics to study the biomechanics of static and dynamic loading conditions on the skin, dermatological and sports injuries, and estimating the dynamic load response of lethal and nonlethal ballistics. To date, human skin surrogates have been developed mainly with materials, such as gelatin and polydimethylsiloxane (PDMS), based on assumption of simplified mechanical properties, such as an average elastic modulus (estimated through indentation tests), and Poisson’s ratio. In addition, pigskin and cowhides, which have widely varying mechanical properties, have been used to simulate human skin. In the current work, a novel elastomer-based material system is developed, which precisely mimics the nonlinear stress–stretch behavior, elastic modulus at high and low strains, and fracture strengths of the natural human skin at different body sites. The manufacturing and fabrication process of these skin surrogates are discussed, and mechanical testing results are presented. |
format | Online Article Text |
id | pubmed-6352690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63526902019-05-16 Biomechanical Modeling of Human Skin Tissue Surrogates Chanda, Arnab Biomimetics (Basel) Article Surrogates, which precisely simulate nonlinear mechanical properties of the human skin at different body sites, would be indispensable for biomechanical testing applications, such as estimating the accurate load response of skin implants and prosthetics to study the biomechanics of static and dynamic loading conditions on the skin, dermatological and sports injuries, and estimating the dynamic load response of lethal and nonlethal ballistics. To date, human skin surrogates have been developed mainly with materials, such as gelatin and polydimethylsiloxane (PDMS), based on assumption of simplified mechanical properties, such as an average elastic modulus (estimated through indentation tests), and Poisson’s ratio. In addition, pigskin and cowhides, which have widely varying mechanical properties, have been used to simulate human skin. In the current work, a novel elastomer-based material system is developed, which precisely mimics the nonlinear stress–stretch behavior, elastic modulus at high and low strains, and fracture strengths of the natural human skin at different body sites. The manufacturing and fabrication process of these skin surrogates are discussed, and mechanical testing results are presented. MDPI 2018-07-23 /pmc/articles/PMC6352690/ /pubmed/31105240 http://dx.doi.org/10.3390/biomimetics3030018 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chanda, Arnab Biomechanical Modeling of Human Skin Tissue Surrogates |
title | Biomechanical Modeling of Human Skin Tissue Surrogates |
title_full | Biomechanical Modeling of Human Skin Tissue Surrogates |
title_fullStr | Biomechanical Modeling of Human Skin Tissue Surrogates |
title_full_unstemmed | Biomechanical Modeling of Human Skin Tissue Surrogates |
title_short | Biomechanical Modeling of Human Skin Tissue Surrogates |
title_sort | biomechanical modeling of human skin tissue surrogates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352690/ https://www.ncbi.nlm.nih.gov/pubmed/31105240 http://dx.doi.org/10.3390/biomimetics3030018 |
work_keys_str_mv | AT chandaarnab biomechanicalmodelingofhumanskintissuesurrogates |