Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profile during the course of cell culture processes accurately....

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Detalles Bibliográficos
Autores principales: Sumit, Madhuresh, Dolatshahi, Sepideh, Chu, An-Hsiang Adam, Cote, Kaffa, Scarcelli, John J., Marshall, Jeffrey K., Cornell, Richard J., Weiss, Ron, Lauffenburger, Douglas A., Mulukutla, Bhanu Chandra, Figueroa, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352710/
https://www.ncbi.nlm.nih.gov/pubmed/30682623
http://dx.doi.org/10.1016/j.isci.2019.01.006

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