The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus

Recently, a series of endo-type B polycyclic polyprenylated acylphloroglucinols (PPAP) derivatives with high antimicrobial activities were chemically synthesized. One of the derivatives, PPAP 23, which showed high antimicrobial activity and low cytotoxicity, was chosen for further investigation of i...

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Detalles Bibliográficos
Autores principales: Wang, Huanhuan, Kraus, Frank, Popella, Peter, Baykal, Aslihan, Guttroff, Claudia, François, Patrice, Sass, Peter, Plietker, Bernd, Götz, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352742/
https://www.ncbi.nlm.nih.gov/pubmed/30728811
http://dx.doi.org/10.3389/fmicb.2019.00014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352742/
https://www.ncbi.nlm.nih.gov/pubmed/30728811
http://dx.doi.org/10.3389/fmicb.2019.00014

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