Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5(+) Stem Cells via Inhibition of Wnt and Notch Signaling

BACKGROUND & AIMS: Epithelial regeneration is essential for homeostasis and repair of the mucosal barrier. In the context of infectious and immune-mediated intestinal disease, interleukin (IL) 22 is thought to augment these processes. We sought to define the mechanisms by which IL22 promotes muc...

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Detalles Bibliográficos
Autores principales: Zha, Juan-Min, Li, Hua-Shan, Lin, Qian, Kuo, Wei-Ting, Jiang, Zhi-Hui, Tsai, Pei-Yun, Ding, Ning, Wu, Jia, Xu, Shao-Fang, Wang, Yi-Tang, Pan, Jian, Zhou, Xiu-Min, Chen, Kai, Tao, Min, Odenwald, Matthew A., Tamura, Atsushi, Tsukita, Sachiko, Turner, Jerrold R., He, Wei-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352747/
https://www.ncbi.nlm.nih.gov/pubmed/30686779
http://dx.doi.org/10.1016/j.jcmgh.2018.09.006

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