Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of the side effects associated to prolonged MAGL inacti...

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Detalles Bibliográficos
Autores principales: Poli, Giulio, Lapillo, Margherita, Jha, Vibhu, Mouawad, Nayla, Caligiuri, Isabella, Macchia, Marco, Minutolo, Filippo, Rizzolio, Flavio, Tuccinardi, Tiziano, Granchi, Carlotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352951/
https://www.ncbi.nlm.nih.gov/pubmed/30696302
http://dx.doi.org/10.1080/14756366.2019.1571271

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