Cargando…

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been largely studied as a potential target for the tre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deplano, Alessandro, Cipriano, Mariateresa, Moraca, Federica, Novellino, Ettore, Catalanotti, Bruno, Fowler, Christopher J., Onnis, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352954/ https://www.ncbi.nlm.nih.gov/pubmed/30688118 http://dx.doi.org/10.1080/14756366.2018.1532418

Ejemplares similares

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
por: Deplano, Alessandro, et al.
Publicado: (2020)

Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents
por: Deplano, Alessandro, et al.
Publicado: (2021)

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode
por: Karlsson, Jessica, et al.
Publicado: (2015)

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor
por: Gouveia-Figueira, Sandra, et al.
Publicado: (2015)

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
por: Sunduru, Naresh, et al.
Publicado: (2017)

Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition
por: Morgillo, Carmine Marco, et al.
Publicado: (2022)

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study
por: Björklund, Emmelie, et al.
Publicado: (2014)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018)

Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
por: D'Addario, Claudio, et al.
Publicado: (2012)

Hydrolysis of Ibuprofen Nitrile and Ibuprofen Amide and Deracemisation of Ibuprofen Using Nocardia corallina B-276
por: Lievano, Ricardo, et al.
Publicado: (2012)

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity
por: Mofford, David M., et al.
Publicado: (2015)

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals
por: Cannalire, Rolando, et al.
Publicado: (2020)

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase
por: Qiu, Yan, et al.
Publicado: (2016)

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase
por: Sabatucci, Annalaura, et al.
Publicado: (2019)

Carboxymethyl benzylamide dextran inhibits angiogenesis and growth of VEGF-overexpressing human epidermoid carcinoma xenograft in nude mice
por: Hamma-Kourbali, Y, et al.
Publicado: (2003)

In Vitro Evaluation of the Antimicrobial Ability and Cytotoxicity on Two Melanoma Cell Lines of a Benzylamide Derivative of Maslinic Acid
por: Pavel, Ioana Zinuca, et al.
Publicado: (2016)

Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization
por: Grieco, Maddalena, et al.
Publicado: (2021)

Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
por: Lueneberg, Kathia, et al.
Publicado: (2011)

Overexpression of Fatty Acid Amide Hydrolase Induces Early Flowering in Arabidopsis thaliana
por: Teaster, Neal D., et al.
Publicado: (2012)

Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis
por: Rieck, Sarah, et al.
Publicado: (2021)

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer
por: Tundidor, Isabel, et al.
Publicado: (2023)

Radiosynthesis and Evaluation of [(11)C-Carbonyl]-Labeled Carbamates as Fatty Acid Amide Hydrolase Radiotracers for Positron Emission Tomography
por: Wilson, Alan A., et al.
Publicado: (2012)

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice
por: Cassano, Tommaso, et al.
Publicado: (2010)

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
por: Sirrs, Sandra, et al.
Publicado: (2015)

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015)

PET Imaging of Fatty Acid Amide Hydrolase with [(18)F]DOPP in Nonhuman Primates
por: Rotstein, Benjamin H., et al.
Publicado: (2014)

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
por: Carey, Lawrence M, et al.
Publicado: (2016)

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition
por: Palermo, Giulia, et al.
Publicado: (2015)

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding
por: Sekiba, Kazuma, et al.
Publicado: (2020)

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474
por: Bonifácio, Maria‐João, et al.
Publicado: (2020)

Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation
por: Green, Duncan GJ., et al.
Publicado: (2022)

Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice
por: Contarini, Gabriella, et al.
Publicado: (2019)

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety
por: Carnevali, Luca, et al.
Publicado: (2015)

Fatty Acid Amide Hydrolase in Prostate Cancer: Association with Disease Severity and Outcome, CB(1) Receptor Expression and Regulation by IL-4
por: Thors, Lina, et al.
Publicado: (2010)

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats
por: Vinod, K. Yaragudri, et al.
Publicado: (2012)

A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain
por: Benson, N, et al.
Publicado: (2014)

Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice
por: Helfand, Alexander I., et al.
Publicado: (2017)

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors
por: Criscuolo, Emanuele, et al.
Publicado: (2020)

Para-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, Synthesis and Biological Evaluation
por: Sedaghat, Anna, et al.
Publicado: (2020)

Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats
por: Zubrzycki, Marek, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rm5b3erjs96jehnuh1ia87pn1p