Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.

Detalles Bibliográficos
Autores principales: Goldhamer, David J, Lees-Shepard, John B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353591/
https://www.ncbi.nlm.nih.gov/pubmed/30698142
http://dx.doi.org/10.7554/eLife.43928
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author Goldhamer, David J
Lees-Shepard, John B
author_facet Goldhamer, David J
Lees-Shepard, John B
author_sort Goldhamer, David J
collection PubMed
description We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.
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spelling pubmed-63535912019-02-01 Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity' Goldhamer, David J Lees-Shepard, John B eLife Human Biology and Medicine We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva. eLife Sciences Publications, Ltd 2019-01-30 /pmc/articles/PMC6353591/ /pubmed/30698142 http://dx.doi.org/10.7554/eLife.43928 Text en © 2019, Goldhamer and Lees-Shepard http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Goldhamer, David J
Lees-Shepard, John B
Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title_full Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title_fullStr Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title_full_unstemmed Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title_short Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
title_sort response to comment on 'palovarotene reduces heterotopic ossification in juvenile fop mice but exhibits pronounced skeletal toxicity'
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353591/
https://www.ncbi.nlm.nih.gov/pubmed/30698142
http://dx.doi.org/10.7554/eLife.43928
work_keys_str_mv AT goldhamerdavidj responsetocommentonpalovarotenereducesheterotopicossificationinjuvenilefopmicebutexhibitspronouncedskeletaltoxicity
AT leesshepardjohnb responsetocommentonpalovarotenereducesheterotopicossificationinjuvenilefopmicebutexhibitspronouncedskeletaltoxicity

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