TCR Repertoire Analysis Reveals Mobilization of Novel CD8(+) T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration

Depletion of CD4(+) cells using an anti-CD4 monoclonal antibody (anti-CD4 mAb) induces the expansion of tumor-reactive CD8(+) T cells and strong antitumor effects in several murine tumor models. However, it is not known whether the anti-CD4 mAb treatment activates a particular or a broad spectrum of...

Descripción completa

Detalles Bibliográficos
Autores principales: Aoki, Hiroyasu, Ueha, Satoshi, Shichino, Shigeyuki, Ogiwara, Haru, Hashimoto, Shin-ichi, Kakimi, Kazuhiro, Ito, Satoru, Matsushima, Kouji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353793/
https://www.ncbi.nlm.nih.gov/pubmed/30733724
http://dx.doi.org/10.3389/fimmu.2018.03185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353793/
https://www.ncbi.nlm.nih.gov/pubmed/30733724
http://dx.doi.org/10.3389/fimmu.2018.03185

Ejemplares similares