Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

Objective: Inspired by the traditionally clinical application of herb pair Zhimu-Huangbo to treat diabetes, a combination of plant ingredients, timosaponin B2 (TB-2) and berberine (BBR), was evaluated for their anti-diabetic efficacy and cooperative mechanisms. Methods: The efficacy and pharmacokine...

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Detalles Bibliográficos
Autores principales: Tian, Xiaoting, Liu, Fang, Li, Zhixiong, Lin, Yunfei, Liu, Huan, Hu, Pei, Chen, Mingcang, Sun, Zhaolin, Xu, Zhou, Zhang, Yiting, Han, Li, Zhang, Yuanyuan, Pan, Guoyu, Huang, Chenggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353801/
https://www.ncbi.nlm.nih.gov/pubmed/30733676
http://dx.doi.org/10.3389/fphar.2019.00019

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