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The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body. In addition to this transport function, transthyretin has also been involved in cardiovascular malfunctions, polyneuropathy, psychological disor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353848/ https://www.ncbi.nlm.nih.gov/pubmed/30733681 http://dx.doi.org/10.3389/fphys.2019.00005 |
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author | Sharma, Meesha Khan, Sheeza Rahman, Safikur Singh, Laishram Rajendrakumar |
author_facet | Sharma, Meesha Khan, Sheeza Rahman, Safikur Singh, Laishram Rajendrakumar |
author_sort | Sharma, Meesha |
collection | PubMed |
description | The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body. In addition to this transport function, transthyretin has also been involved in cardiovascular malfunctions, polyneuropathy, psychological disorders, obesity and diabetes, etc. Recent developments have evidenced that transthyretin has been associated with many other biological functions that are directly or indirectly associated with the oxidative stress, the common hallmark for many human diseases. In this review, we have attempted to address that transthyretin is associated with oxidative stress and could be an important biomarker. Potential future perspectives have also been discussed. |
format | Online Article Text |
id | pubmed-6353848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63538482019-02-07 The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker Sharma, Meesha Khan, Sheeza Rahman, Safikur Singh, Laishram Rajendrakumar Front Physiol Physiology The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body. In addition to this transport function, transthyretin has also been involved in cardiovascular malfunctions, polyneuropathy, psychological disorders, obesity and diabetes, etc. Recent developments have evidenced that transthyretin has been associated with many other biological functions that are directly or indirectly associated with the oxidative stress, the common hallmark for many human diseases. In this review, we have attempted to address that transthyretin is associated with oxidative stress and could be an important biomarker. Potential future perspectives have also been discussed. Frontiers Media S.A. 2019-01-24 /pmc/articles/PMC6353848/ /pubmed/30733681 http://dx.doi.org/10.3389/fphys.2019.00005 Text en Copyright © 2019 Sharma, Khan, Rahman and Singh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Sharma, Meesha Khan, Sheeza Rahman, Safikur Singh, Laishram Rajendrakumar The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title | The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title_full | The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title_fullStr | The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title_full_unstemmed | The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title_short | The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker |
title_sort | extracellular protein, transthyretin is an oxidative stress biomarker |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353848/ https://www.ncbi.nlm.nih.gov/pubmed/30733681 http://dx.doi.org/10.3389/fphys.2019.00005 |
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