A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics

Inhibition of the NGF/TrkA interaction presents an interesting alternative to the use of non-steroidal anti-inflammatories and/or opioids for the control of inflammatory, chronic and neuropathic pain. Most prominent of the current approaches to this therapy is the antibody Tanezumab, which is a late...

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Detalles Bibliográficos
Autores principales: Poole, Andrew J., Frigotto, Laura, Smith, Matthew E., Baar, Claudia, Ivanova-Berndt, Gabriela, Jaulent, Agnes, Stace, Catherine, Ullman, Christopher G., Hine, Anna V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353895/
https://www.ncbi.nlm.nih.gov/pubmed/30700786
http://dx.doi.org/10.1038/s41598-018-37585-5

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