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The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

The mechanisms controlling CD4(+) T cell switching from an effector to an anti-inflammatory (IL-10(+)) phenotype play an important role in the persistence of chronic inflammatory diseases. Here, we identify the cholesterol biosynthesis pathway as a key regulator of this process. Pathway analysis of...

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Detalles Bibliográficos
Autores principales:	Perucha, Esperanza, Melchiotti, Rossella, Bibby, Jack A, Wu, Wing, Frederiksen, Klaus Stensgaard, Roberts, Ceri A., Hall, Zoe, LeFriec, Gaelle, Robertson, Kevin A., Lavender, Paul, Gerwien, Jens Gammeltoft, Taams, Leonie S., Griffin, Julian L., de Rinaldis, Emanuele, van Baarsen, Lisa G. M., Kemper, Claudia, Ghazal, Peter, Cope, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353904/ https://www.ncbi.nlm.nih.gov/pubmed/30700717 http://dx.doi.org/10.1038/s41467-019-08332-9

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