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Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia

Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study,...

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Autores principales: Simonsen, Arndis, Fusaroli, Riccardo, Skewes, Joshua Charles, Roepstorff, Andreas, Mors, Ole, Bliksted, Vibeke, Campbell-Meiklejohn, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353936/
https://www.ncbi.nlm.nih.gov/pubmed/30700729
http://dx.doi.org/10.1038/s41598-018-37250-x
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author Simonsen, Arndis
Fusaroli, Riccardo
Skewes, Joshua Charles
Roepstorff, Andreas
Mors, Ole
Bliksted, Vibeke
Campbell-Meiklejohn, Daniel
author_facet Simonsen, Arndis
Fusaroli, Riccardo
Skewes, Joshua Charles
Roepstorff, Andreas
Mors, Ole
Bliksted, Vibeke
Campbell-Meiklejohn, Daniel
author_sort Simonsen, Arndis
collection PubMed
description Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study, we specifically investigated whether patients display a reduced tendency to adopt other people’s opinions (socially learned attitude change). We administered a computerized conformity task, assumed to rely on reinforcement learning circuits, to 32 patients with schizophrenia or schizo-affective disorder and 39 matched controls. Each participant rated 153 faces for trustworthiness. After each rating, they were immediately shown the opinion of a group. After approximately 1 hour, participants were unexpectedly asked to rate all the faces again. We compared the degree of attitude change towards group opinion in patients and controls. Patients presented equal or more social influence on attitudes than controls. This effect may have been medication induced, as increased conformity was seen with higher antipsychotic dose. The results suggest that there is not a general decline in conformity in medicated patients with schizophrenia and that previous findings of reduced conformity are likely related to mechanisms other than reinforcement based social influence on attitudes.
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spelling pubmed-63539362019-02-01 Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia Simonsen, Arndis Fusaroli, Riccardo Skewes, Joshua Charles Roepstorff, Andreas Mors, Ole Bliksted, Vibeke Campbell-Meiklejohn, Daniel Sci Rep Article Schizophrenia is often associated with distinctive or odd social behaviours. Previous work suggests this could be due to a general reduction in conformity; however, this work only assessed the tendency to publicly agree with others, which may involve a number of different mechanisms. In this study, we specifically investigated whether patients display a reduced tendency to adopt other people’s opinions (socially learned attitude change). We administered a computerized conformity task, assumed to rely on reinforcement learning circuits, to 32 patients with schizophrenia or schizo-affective disorder and 39 matched controls. Each participant rated 153 faces for trustworthiness. After each rating, they were immediately shown the opinion of a group. After approximately 1 hour, participants were unexpectedly asked to rate all the faces again. We compared the degree of attitude change towards group opinion in patients and controls. Patients presented equal or more social influence on attitudes than controls. This effect may have been medication induced, as increased conformity was seen with higher antipsychotic dose. The results suggest that there is not a general decline in conformity in medicated patients with schizophrenia and that previous findings of reduced conformity are likely related to mechanisms other than reinforcement based social influence on attitudes. Nature Publishing Group UK 2019-01-30 /pmc/articles/PMC6353936/ /pubmed/30700729 http://dx.doi.org/10.1038/s41598-018-37250-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Simonsen, Arndis
Fusaroli, Riccardo
Skewes, Joshua Charles
Roepstorff, Andreas
Mors, Ole
Bliksted, Vibeke
Campbell-Meiklejohn, Daniel
Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title_full Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title_fullStr Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title_full_unstemmed Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title_short Socially Learned Attitude Change is not reduced in Medicated Patients with Schizophrenia
title_sort socially learned attitude change is not reduced in medicated patients with schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353936/
https://www.ncbi.nlm.nih.gov/pubmed/30700729
http://dx.doi.org/10.1038/s41598-018-37250-x
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