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Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study

Necrotizing enterocolitis (NEC) is the leading cause of death among infants born at <30 weeks’ gestation, but donor human milk can reduce the incidence of NEC. Unfortunately, freezing or pasteurizing human milk deactivates beneficial bioactive components. We evaluated the feasibility, safety, and...

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Autores principales: Sun, Huiqing, Han, Shuping, Cheng, Rui, Hei, Mingyan, Kakulas, Foteini, Lee, Shoo K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353969/
https://www.ncbi.nlm.nih.gov/pubmed/30700726
http://dx.doi.org/10.1038/s41598-018-37111-7
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author Sun, Huiqing
Han, Shuping
Cheng, Rui
Hei, Mingyan
Kakulas, Foteini
Lee, Shoo K.
author_facet Sun, Huiqing
Han, Shuping
Cheng, Rui
Hei, Mingyan
Kakulas, Foteini
Lee, Shoo K.
author_sort Sun, Huiqing
collection PubMed
description Necrotizing enterocolitis (NEC) is the leading cause of death among infants born at <30 weeks’ gestation, but donor human milk can reduce the incidence of NEC. Unfortunately, freezing or pasteurizing human milk deactivates beneficial bioactive components. We evaluated the feasibility, safety, and impact of feeding very preterm infants fresh (unprocessed) mother’s own milk within 4 hours of expression. In our multicentre prospective cohort analytic study, we fed 109 control and 98 intervention infants previously frozen donor or mother’s own milk; only the intervention group was fed fresh mother’s own milk once daily from enrollment until 32 weeks’ corrected age. Control group mothers could not commit to provide fresh milk daily and were less likely receive antenatal corticosteroids than mothers in the intervention group. In the intervention group, 87.5% (98/112) of mothers were able to provide at least one feed of fresh milk a day. No critical incidents or non-compliance with the protocol were reported. The duration of mechanical ventilation and total parenteral nutrition use were shorter in the intervention group than controls (P < 0.01) but the length of hospital stay was similar (P = 0.57). Although the study might be underpowered, the intervention group had lower unadjusted rates of the composite outcome NEC ≥ stage 2 or mortality (8% vs 20%, P = 0.04), sepsis (22% vs 38%, P = 0.02), retinopathy of prematurity (17% vs 39%, P < 0.01) and bronchopulmonary dysplasia (32% vs 47%, P < 0.01) than the control. These results indicated that feeding fresh mother’s own milk once daily was safe, feasible, and may reduce morbidity.
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spelling pubmed-63539692019-02-01 Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study Sun, Huiqing Han, Shuping Cheng, Rui Hei, Mingyan Kakulas, Foteini Lee, Shoo K. Sci Rep Article Necrotizing enterocolitis (NEC) is the leading cause of death among infants born at <30 weeks’ gestation, but donor human milk can reduce the incidence of NEC. Unfortunately, freezing or pasteurizing human milk deactivates beneficial bioactive components. We evaluated the feasibility, safety, and impact of feeding very preterm infants fresh (unprocessed) mother’s own milk within 4 hours of expression. In our multicentre prospective cohort analytic study, we fed 109 control and 98 intervention infants previously frozen donor or mother’s own milk; only the intervention group was fed fresh mother’s own milk once daily from enrollment until 32 weeks’ corrected age. Control group mothers could not commit to provide fresh milk daily and were less likely receive antenatal corticosteroids than mothers in the intervention group. In the intervention group, 87.5% (98/112) of mothers were able to provide at least one feed of fresh milk a day. No critical incidents or non-compliance with the protocol were reported. The duration of mechanical ventilation and total parenteral nutrition use were shorter in the intervention group than controls (P < 0.01) but the length of hospital stay was similar (P = 0.57). Although the study might be underpowered, the intervention group had lower unadjusted rates of the composite outcome NEC ≥ stage 2 or mortality (8% vs 20%, P = 0.04), sepsis (22% vs 38%, P = 0.02), retinopathy of prematurity (17% vs 39%, P < 0.01) and bronchopulmonary dysplasia (32% vs 47%, P < 0.01) than the control. These results indicated that feeding fresh mother’s own milk once daily was safe, feasible, and may reduce morbidity. Nature Publishing Group UK 2019-01-30 /pmc/articles/PMC6353969/ /pubmed/30700726 http://dx.doi.org/10.1038/s41598-018-37111-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sun, Huiqing
Han, Shuping
Cheng, Rui
Hei, Mingyan
Kakulas, Foteini
Lee, Shoo K.
Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title_full Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title_fullStr Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title_full_unstemmed Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title_short Testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the NICU: A pilot study
title_sort testing the feasibility and safety of feeding preterm infants fresh mother’s own milk in the nicu: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353969/
https://www.ncbi.nlm.nih.gov/pubmed/30700726
http://dx.doi.org/10.1038/s41598-018-37111-7
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