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Sarcomatoid carcinoma of the pancreas: A case report

BACKGROUND: Sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelial differentiation. And the term “sarcomatoid carcinoma” is often confused with “c...

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Autores principales: Zhou, Dong-Kai, Gao, Bing-Qiang, Zhang, Wang, Qian, Xiao-Hui, Ying, Li-Xiong, Wang, Wei-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354085/
https://www.ncbi.nlm.nih.gov/pubmed/30705901
http://dx.doi.org/10.12998/wjcc.v7.i2.236
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author Zhou, Dong-Kai
Gao, Bing-Qiang
Zhang, Wang
Qian, Xiao-Hui
Ying, Li-Xiong
Wang, Wei-Lin
author_facet Zhou, Dong-Kai
Gao, Bing-Qiang
Zhang, Wang
Qian, Xiao-Hui
Ying, Li-Xiong
Wang, Wei-Lin
author_sort Zhou, Dong-Kai
collection PubMed
description BACKGROUND: Sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelial differentiation. And the term “sarcomatoid carcinoma” is often confused with “carcinosarcoma”. CASE SUMMARY: We present a case of SCP with lymph node metastasis in a 59-year-old male patient. He had experienced darkening of the urine, scleral icterus, and fatigue for 4 weeks. Computed tomography and magnetic resonance imaging revealed a mass in the pancreatic head, and laboratory tests revealed elevated serum bilirubin levels. The patient underwent pancreaticoduodenectomy after biliary decompression. Histologically, spindle cells with marked nuclear atypia and brisk mitotic activity arranged in a storiform or fascicular pattern were present in the bulk of the tumor. Immunohistochemical analysis found that the spindle cells exhibited strong diffuse positivity for epithelial markers, indicative of epithelial differentiation. Accordingly, the pathologic diagnosis of the pancreatic neoplasm was SCP. CONCLUSION: Although sarcomatoid carcinomas and carcinosarcomas have different pathologic features, both have epithelial origin.
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spelling pubmed-63540852019-01-31 Sarcomatoid carcinoma of the pancreas: A case report Zhou, Dong-Kai Gao, Bing-Qiang Zhang, Wang Qian, Xiao-Hui Ying, Li-Xiong Wang, Wei-Lin World J Clin Cases Case Report BACKGROUND: Sarcomatoid carcinoma of the pancreas (SCP) is a rare and aggressive epithelial tumor that has both epithelial and mesenchymal features. It is characterized by sarcomatous elements with evidence of epithelial differentiation. And the term “sarcomatoid carcinoma” is often confused with “carcinosarcoma”. CASE SUMMARY: We present a case of SCP with lymph node metastasis in a 59-year-old male patient. He had experienced darkening of the urine, scleral icterus, and fatigue for 4 weeks. Computed tomography and magnetic resonance imaging revealed a mass in the pancreatic head, and laboratory tests revealed elevated serum bilirubin levels. The patient underwent pancreaticoduodenectomy after biliary decompression. Histologically, spindle cells with marked nuclear atypia and brisk mitotic activity arranged in a storiform or fascicular pattern were present in the bulk of the tumor. Immunohistochemical analysis found that the spindle cells exhibited strong diffuse positivity for epithelial markers, indicative of epithelial differentiation. Accordingly, the pathologic diagnosis of the pancreatic neoplasm was SCP. CONCLUSION: Although sarcomatoid carcinomas and carcinosarcomas have different pathologic features, both have epithelial origin. Baishideng Publishing Group Inc 2019-01-26 2019-01-26 /pmc/articles/PMC6354085/ /pubmed/30705901 http://dx.doi.org/10.12998/wjcc.v7.i2.236 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Zhou, Dong-Kai
Gao, Bing-Qiang
Zhang, Wang
Qian, Xiao-Hui
Ying, Li-Xiong
Wang, Wei-Lin
Sarcomatoid carcinoma of the pancreas: A case report
title Sarcomatoid carcinoma of the pancreas: A case report
title_full Sarcomatoid carcinoma of the pancreas: A case report
title_fullStr Sarcomatoid carcinoma of the pancreas: A case report
title_full_unstemmed Sarcomatoid carcinoma of the pancreas: A case report
title_short Sarcomatoid carcinoma of the pancreas: A case report
title_sort sarcomatoid carcinoma of the pancreas: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354085/
https://www.ncbi.nlm.nih.gov/pubmed/30705901
http://dx.doi.org/10.12998/wjcc.v7.i2.236
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